1l8w
From Proteopedia
(New page: 200px<br /><applet load="1l8w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l8w, resolution 2.30Å" /> '''Crystal Structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1l8w.gif|left|200px]]<br /><applet load="1l8w" size=" | + | [[Image:1l8w.gif|left|200px]]<br /><applet load="1l8w" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1l8w, resolution 2.30Å" /> | caption="1l8w, resolution 2.30Å" /> | ||
'''Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi'''<br /> | '''Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi'''<br /> | ||
==Overview== | ==Overview== | ||
| - | VlsE is an outer surface lipoprotein of Borrelia burgdorferi that | + | VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion. |
==About this Structure== | ==About this Structure== | ||
| - | 1L8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http:// | + | 1L8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Eicken, C.]] | [[Category: Eicken, C.]] | ||
| - | [[Category: Hardham, J | + | [[Category: Hardham, J M.]] |
[[Category: Klabunde, T.]] | [[Category: Klabunde, T.]] | ||
| - | [[Category: Lawrenz, M | + | [[Category: Lawrenz, M B.]] |
| - | [[Category: Norris, S | + | [[Category: Norris, S J.]] |
| - | [[Category: Sacchettini, J | + | [[Category: Sacchettini, J C.]] |
[[Category: Sharma, V.]] | [[Category: Sharma, V.]] | ||
[[Category: variable surface protein]] | [[Category: variable surface protein]] | ||
[[Category: vmp-like sequence]] | [[Category: vmp-like sequence]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:42:36 2008'' |
Revision as of 11:42, 21 February 2008
|
Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi
Overview
VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.
About this Structure
1L8W is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.
Reference
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi., Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC, J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28. PMID:11923306
Page seeded by OCA on Thu Feb 21 13:42:36 2008
