3jsu
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[3jsu]] is a 2 chain structure | + | [[3jsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. |
==See Also== | ==See Also== | ||
Revision as of 08:10, 20 October 2012
Contents |
Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP
Template:ABSTRACT PUBMED 20350951
About this Structure
3jsu is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
See Also
Reference
- Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT. Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. Epub 2010 Mar 29. PMID:20350951 doi:10.1128/AAC.01526-09
