1mof
From Proteopedia
(New page: 200px<br /><applet load="1mof" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mof, resolution 1.7Å" /> '''COAT PROTEIN'''<br />...) |
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| - | [[Image:1mof.jpg|left|200px]]<br /><applet load="1mof" size=" | + | [[Image:1mof.jpg|left|200px]]<br /><applet load="1mof" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mof, resolution 1.7Å" /> | caption="1mof, resolution 1.7Å" /> | ||
'''COAT PROTEIN'''<br /> | '''COAT PROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We report the crystal structure of an extraviral segment of a retrovirus | + | We report the crystal structure of an extraviral segment of a retrovirus envelope protein, the Moloney murine leukemia virus (MoMuLV) transmembrane (TM) subunit. This segment, which comprises a region of the MoMuLV TM protein analogous to that contained within the X-ray crystal structure of low-pH converted influenza hemagglutinin, contains a trimeric coiled coil, with a hydrophobic cluster at its base and a strand that packs in an antiparallel orientation against the coiled coil. This structure gives the first high-resolution insight into the retrovirus surface and serves as a model for a wide range of viral fusion proteins; key residues in this structure are conserved among C- and D-type retroviruses and the filovirus ebola. |
==About this Structure== | ==About this Structure== | ||
| - | 1MOF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MOF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fass, D.]] | [[Category: Fass, D.]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
| - | [[Category: Kim, P | + | [[Category: Kim, P S.]] |
[[Category: CL]] | [[Category: CL]] | ||
[[Category: coat protein]] | [[Category: coat protein]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:18 2008'' |
Revision as of 11:57, 21 February 2008
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COAT PROTEIN
Overview
We report the crystal structure of an extraviral segment of a retrovirus envelope protein, the Moloney murine leukemia virus (MoMuLV) transmembrane (TM) subunit. This segment, which comprises a region of the MoMuLV TM protein analogous to that contained within the X-ray crystal structure of low-pH converted influenza hemagglutinin, contains a trimeric coiled coil, with a hydrophobic cluster at its base and a strand that packs in an antiparallel orientation against the coiled coil. This structure gives the first high-resolution insight into the retrovirus surface and serves as a model for a wide range of viral fusion proteins; key residues in this structure are conserved among C- and D-type retroviruses and the filovirus ebola.
About this Structure
1MOF is a Single protein structure of sequence from Moloney murine leukemia virus with as ligand. Full crystallographic information is available from OCA.
Reference
Retrovirus envelope domain at 1.7 angstrom resolution., Fass D, Harrison SC, Kim PS, Nat Struct Biol. 1996 May;3(5):465-9. PMID:8612078
Page seeded by OCA on Thu Feb 21 13:57:18 2008
