Calpain
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='1kxr' size='400' side='right' caption='Structure of rat cslpsin1 protease domain complex with Ca+2 (PDB entry [[1kxr]])' scene=''> | + | <StructureSection load='1kxr' size='400' side='right' caption='Structure of rat cslpsin1 protease domain dimer complex with Ca+2 (PDB entry [[1kxr]])' scene=''> |
'''Calpains''' (CAP) are calcium-dependent cysteine proteases. The CAP family contains 14 members. CAP is a heterodimer containing a small28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. The best characterized CAPs are CAP1 (or mu-CAP) and CAP2 (or M-CAP). CAP7 is atypical CAP that lacks a penta-EF-hand domain. CAP8 and CAP9 are involved in the mucosal defense against stress-induced gastropathies. CAP9 has been identified as the tumor suppressor for gastric cancer. CAP13 is expressed in testis and lungs. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin. | '''Calpains''' (CAP) are calcium-dependent cysteine proteases. The CAP family contains 14 members. CAP is a heterodimer containing a small28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. The best characterized CAPs are CAP1 (or mu-CAP) and CAP2 (or M-CAP). CAP7 is atypical CAP that lacks a penta-EF-hand domain. CAP8 and CAP9 are involved in the mucosal defense against stress-induced gastropathies. CAP9 has been identified as the tumor suppressor for gastric cancer. CAP13 is expressed in testis and lungs. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin. | ||
Revision as of 10:44, 25 October 2012
| |||||||||||
