Sandbox Reserved 652

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== Introduction ==
== Introduction ==
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'''Alanine aminotransferase'''(ALT), also known as L-alanine:2-oxoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. It's half-life is approximately 48 h. [acb.org.uk]
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'''Alanine aminotransferase'''(ALT), also known as L-alanine:2-oxoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. It's half-life is approximately 48 h. [acb.org.uk] ALT's main function is to catalyze the transfer of amino groups from alanine. ALT forms pyruvate from α-ketoglutarate. It is a key enzyme in gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or [necrosis]. High levels of ALT could be a response to high alcohol intake, [obesity], [diabetes], and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.
<StructureSection load='3ihj' size='350' side='right' caption='3D visual of human alanine aminotransferase 2 in complex with PLP (PDB entry [[3ihj]])' scene=''>
<StructureSection load='3ihj' size='350' side='right' caption='3D visual of human alanine aminotransferase 2 in complex with PLP (PDB entry [[3ihj]])' scene=''>

Revision as of 20:42, 18 November 2012

This Sandbox is Reserved from 30/08/2012, through 01/02/2013 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 636 through Sandbox Reserved 685.
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Alanine Aminotransferase

Introduction

Alanine aminotransferase(ALT), also known as L-alanine:2-oxoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. It's half-life is approximately 48 h. [acb.org.uk] ALT's main function is to catalyze the transfer of amino groups from alanine. ALT forms pyruvate from α-ketoglutarate. It is a key enzyme in gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or [necrosis]. High levels of ALT could be a response to high alcohol intake, [obesity], [diabetes], and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.

3D visual of human alanine aminotransferase 2 in complex with PLP (PDB entry 3ihj)

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PDB ID 3ihj

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3ihj, resolution 2.30Å ()
Ligands: ,
Gene: GPT2, AAT2, ALT2 (Homo sapiens)
Activity: Alanine transaminase, with EC number 2.6.1.2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


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