Sandbox Reserved 652

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== Introduction ==
== Introduction ==
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'''Alanine aminotransferase''' (ALT), also known as L-alanine:α-ketoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. ALT's main function is to catalyze the transfer of amino groups from alanine to form pyruvate from α-ketoglutarate, which is a key intermediate of gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or [necrosis]. High levels of ALT could be a response to high alcohol intake, [[http://en.wikipedia.org/wiki/Obesity obesity]], [diabetes], and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.
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'''Alanine aminotransferase''' (ALT), also known as L-alanine:α-ketoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. ALT's main function is to catalyze the transfer of amino groups from alanine to form pyruvate from α-ketoglutarate, which is a key intermediate of gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or [necrosis]. High levels of ALT could be a response to high alcohol intake, [http://en.wikipedia.org/wiki/Obesity obesity], [diabetes], and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.

Revision as of 21:25, 18 November 2012

This Sandbox is Reserved from 30/08/2012, through 01/02/2013 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 636 through Sandbox Reserved 685.
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Alanine Aminotransferase

3D visual of human alanine aminotransferase 2 in complex with PLP (PDB entry 3ihj)

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PDB ID 3ihj

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3ihj, resolution 2.30Å ()
Ligands: ,
Gene: GPT2, AAT2, ALT2 (Homo sapiens)
Activity: Alanine transaminase, with EC number 2.6.1.2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Introduction

Alanine aminotransferase (ALT), also known as L-alanine:α-ketoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. ALT's main function is to catalyze the transfer of amino groups from alanine to form pyruvate from α-ketoglutarate, which is a key intermediate of gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or [necrosis]. High levels of ALT could be a response to high alcohol intake, obesity, [diabetes], and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.

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