2x4r

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[[Image:2x4r.png|left|200px]]
 
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{{STRUCTURE_2x4r| PDB=2x4r | SCENE= }}
{{STRUCTURE_2x4r| PDB=2x4r | SCENE= }}
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===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE===
===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE===
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{{ABSTRACT_PUBMED_19655750}}
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{{ABSTRACT_PUBMED_19655750}}
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==Function==
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[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.<ref>PMID:15452220</ref><ref>PMID:20504932</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019655750</ref><references group="xtra"/>
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<ref group="xtra">PMID:019655750</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Celie, P H.N.]]
[[Category: Celie, P H.N.]]

Revision as of 09:47, 24 March 2013

Template:STRUCTURE 2x4r

Contents

CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE

Template:ABSTRACT PUBMED 19655750

Function

[1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system. [PP65_HCMVA] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.[1][2]

About this Structure

2x4r is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Celie PH, Toebes M, Rodenko B, Ovaa H, Perrakis A, Schumacher TN. UV-induced ligand exchange in MHC class I protein crystals. J Am Chem Soc. 2009 Sep 2;131(34):12298-304. PMID:19655750 doi:10.1021/ja9037559
  1. ↑ Abate DA, Watanabe S, Mocarski ES. Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. J Virol. 2004 Oct;78(20):10995-1006. PMID:15452220 doi:10.1128/JVI.78.20.10995-11006.2004
  2. ↑ Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 2010 Aug;84(15):7803-14. doi: 10.1128/JVI.00139-10. Epub 2010 May 26. PMID:20504932 doi:10.1128/JVI.00139-10

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OCA

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