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2lrf
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_2lrf| PDB=2lrf | SCENE= }} | |
| + | ===NMR structure of the Scylla Serrata anti lipopolysaccharide Factor-24 (SsALF-24) peptide=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/ALPS_SCYSE ALPS_SCYSE]] Binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.<ref>PMID:19490944</ref> <ref>PMID:21195157</ref> | ||
| - | + | ==About this Structure== | |
| + | [[2lrf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LRF OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Barnwal, R P.]] | ||
| + | [[Category: Reddy, K V.R.]] | ||
| + | [[Category: Sharma, S.]] | ||
| + | [[Category: Yedery, R.]] | ||
| + | [[Category: Antimicrobial]] | ||
| + | [[Category: Antimicrobial protein]] | ||
Revision as of 01:37, 4 April 2013
Contents |
NMR structure of the Scylla Serrata anti lipopolysaccharide Factor-24 (SsALF-24) peptide
Function
[ALPS_SCYSE] Binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.[1] [2]
About this Structure
2lrf is a 1 chain structure. Full experimental information is available from OCA.
Reference
- ↑ Yedery RD, Reddy KV. Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrata. Fish Shellfish Immunol. 2009 Aug;27(2):275-84. doi: 10.1016/j.fsi.2009.05.009., Epub 2009 May 31. PMID:19490944 doi:10.1016/j.fsi.2009.05.009
- ↑ Sharma S, Yedery RD, Patgaonkar MS, Selvaakumar C, Reddy KV. Antibacterial activity of a synthetic peptide that mimics the LPS binding domain of Indian mud crab, Scylla serrata anti-lipopolysaccharide factor (SsALF) also involved in the modulation of vaginal immune functions through NF-kB signaling. Microb Pathog. 2011 Mar-Apr;50(3-4):179-91. doi: 10.1016/j.micpath.2010.12.007., Epub 2010 Dec 30. PMID:21195157 doi:10.1016/j.micpath.2010.12.007
