Vitamin D receptor

From Proteopedia

(Difference between revisions)

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 <StructureSection load='1db1' size='350' side='right' caption='Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry [[1db1]])' scene=''>
-'''Vitamin D receptor''' (VDR) is a transcription factor.  Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression.  VDR contains a ligand binding domain (LBD) and hormone-binding domain.
+'''Vitamin D receptor''' (VDR) is a transcription factor.  Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression.  VDR contains a ligand binding domain (LBD) and DNA-binding domain (DBD).
 ==3D structures of vitamin D receptor==
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1db1]] – hVDR LBD + vitamin D – human<br />
+===Vitamin D receptor ligand-binding domain===
-[[1txi]], [[2ham]], [[2har]], [[2has]], [[2hb7]], [[2hb8]] - hVDR LBD + vitamin D analog<br />
+[[3m7r]] - hVDR LBD (mutant) – human<br />
+[[1db1]] – hVDR LBD + vitamin D <br />
+[[1s0z]], [[1s19]], [[3a78]], [[4g2i]] - hVDR LBD + vitamin D derivative<br />
+[[3ogt]], [[2ham]], [[2har]],  [[2has]], [[2hb7]], [[2hb8]], [[3p8x]], [[3az1]], [[3az2]], [[3az3]], [[3tkc]] - hVDR LBD + vitamin D analog<br />
+[[3auq]], [[3aur]], [[3kpz]] - hVDR LBD (mutant) + vitamin D analog<br />
+[[3a2i]], [[3a2j]], [[3b0t]], [[3ax8]], [[3vhw]] - hVDR LBD (mutant) + vitamin D derivative<br />
+[[3a3z]], [[3a40]] - hVDR LBD + agonist<br />
+[[1ie8]], [[1ie9]], [[3cs4]], [[3cs6]], [[1txi]] – hVDR LBD + superagonist <br />
+''Vitamin D receptor LBD complex with peptide''
 [[1rjk]], [[1rk3]], [[1rkg]], [[1rkh]], [[2o4j]], [[2o4r]] – rVDR LBD (mutant) + peroxisome proliferator-activated receptor peptide – rat<br />
 [[2zl9]], [[2zla]], [[2zlc]] - rVDR LBD + coactivator peptide DRIP + vitamin D analog<br />
-[[2zfx]], [[3a2h]] - rVDR LBD + coactivator peptide DRIP<br />
+[[3vrt]], [[3vru]], [[3vrv]], [[3vrw]] - rVDR LBD (mutant) + coactivator peptide DRIP + vitamin D analog<br />
-[[3aun]] - rVDR LBD (mutsant) + coactivator peptide DRIP<br />
+[[2zfx]], [[3a2h]], [[2zxm]], [[2zxn]] - rVDR LBD + coactivator peptide DRIP<br />
+[[3aun]], [[2zmh]], [[2zmi]], [[2zmj]], [[3afr]], [[3vjs]], [[3vjt]] - rVDR LBD (mutsant) + coactivator peptide DRIP<br />
 [[2hbh]] - zVDR LBD + steroid receptor coactivator 1 peptide – zebrafish<br />
 [[2hc4]] - zVDR LBD + steroid receptor coactivator 1 peptide + vitamin D<br />
 [[2hcd]] - zVDR LBD + steroid receptor coactivator 1 peptide
+===Vitamin D receptor DNA-binding domain===
+[[1kb2]] – hVDR DBD + osteopontin response element DNA<br />
+[[1kb4]] – hVDR DBD + DR3 response element DNA<br />
+[[1ynw]] – hVDR DBD (mutant) + DR3 response element DNA<br />
+[[1kb6]] – hVDR DBD + osteocalcin response element DNA<br />
 </StructureSection>
 [[Category:Topic Page]]

Revision as of 09:47, 30 April 2013

Image:1db1.png

Crystal structure of human vitamin D receptor ligand-binding domain complex with vitamin D 1db1

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Structure of human vitamin D receptor ligand-binding domain complex with vitamin D (PDB entry 1db1)

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Vitamin D receptor (VDR) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. VDR contains a ligand binding domain (LBD) and DNA-binding domain (DBD).

1 3D structures of vitamin D receptor
2 3D Structures of vitamin D receptor
- 2.1 Vitamin D receptor ligand-binding domain
- 2.2 Vitamin D receptor DNA-binding domain

3D structures of vitamin D receptor

3D Structures of vitamin D receptor

Updated on 30-April-2013

Vitamin D receptor ligand-binding domain

3m7r - hVDR LBD (mutant) – human

1db1 – hVDR LBD + vitamin D

1s0z, 1s19, 3a78, 4g2i - hVDR LBD + vitamin D derivative
3ogt, 2ham, 2har, 2has, 2hb7, 2hb8, 3p8x, 3az1, 3az2, 3az3, 3tkc - hVDR LBD + vitamin D analog
3auq, 3aur, 3kpz - hVDR LBD (mutant) + vitamin D analog
3a2i, 3a2j, 3b0t, 3ax8, 3vhw - hVDR LBD (mutant) + vitamin D derivative
3a3z, 3a40 - hVDR LBD + agonist
1ie8, 1ie9, 3cs4, 3cs6, 1txi – hVDR LBD + superagonist

Vitamin D receptor LBD complex with peptide

1rjk, 1rk3, 1rkg, 1rkh, 2o4j, 2o4r – rVDR LBD (mutant) + peroxisome proliferator-activated receptor peptide – rat

2zl9, 2zla, 2zlc - rVDR LBD + coactivator peptide DRIP + vitamin D analog
3vrt, 3vru, 3vrv, 3vrw - rVDR LBD (mutant) + coactivator peptide DRIP + vitamin D analog
2zfx, 3a2h, 2zxm, 2zxn - rVDR LBD + coactivator peptide DRIP
3aun, 2zmh, 2zmi, 2zmj, 3afr, 3vjs, 3vjt - rVDR LBD (mutsant) + coactivator peptide DRIP
2hbh - zVDR LBD + steroid receptor coactivator 1 peptide – zebrafish
2hc4 - zVDR LBD + steroid receptor coactivator 1 peptide + vitamin D
2hcd - zVDR LBD + steroid receptor coactivator 1 peptide

Vitamin D receptor DNA-binding domain

1kb2 – hVDR DBD + osteopontin response element DNA
1kb4 – hVDR DBD + DR3 response element DNA
1ynw – hVDR DBD (mutant) + DR3 response element DNA
1kb6 – hVDR DBD + osteocalcin response element DNA