3qej
From Proteopedia
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{{STRUCTURE_3qej| PDB=3qej | SCENE= }} | {{STRUCTURE_3qej| PDB=3qej | SCENE= }} | ||
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===S74E-dCK mutant in complex with UDP=== | ===S74E-dCK mutant in complex with UDP=== | ||
| + | {{ABSTRACT_PUBMED_21351740}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | |
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==About this Structure== | ==About this Structure== | ||
[[3qej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEJ OCA]. | [[3qej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEJ OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Deoxycytidine kinase|Deoxycytidine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021351740</ref><references group="xtra"/><references/> |
[[Category: Deoxycytidine kinase]] | [[Category: Deoxycytidine kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hazra, S.]] | [[Category: Hazra, S.]] | ||
[[Category: Lavie, A.]] | [[Category: Lavie, A.]] | ||
| + | [[Category: Alpha/beta]] | ||
| + | [[Category: Atp binding]] | ||
| + | [[Category: Phosphoryl transfer]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:44, 8 May 2013
Contents |
S74E-dCK mutant in complex with UDP
Template:ABSTRACT PUBMED 21351740
Function
[DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.[1] [2]
About this Structure
3qej is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Hazra S, Szewczak A, Ort S, Konrad M, Lavie A. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry. 2011 Feb 25. PMID:21351740 doi:10.1021/bi2001032
- ↑ Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. Epub 2008 Mar 3. PMID:18377927 doi:http://dx.doi.org/10.1016/j.jmb.2008.02.061
- ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
