4g8z

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'''Unreleased structure'''
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{{STRUCTURE_4g8z| PDB=4g8z | SCENE= }}
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===pcDHFR K37S/F69N double mutant TMP NADPH ternary complex===
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{{ABSTRACT_PUBMED_23545530}}
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The entry 4g8z is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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Authors: Cody, V.
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==About this Structure==
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[[4g8z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_jirovecii Pneumocystis jirovecii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8Z OCA].
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Description: pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
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==Reference==
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<ref group="xtra">PMID:023545530</ref><references group="xtra"/><references/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Pneumocystis jirovecii]]
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[[Category: Cody, V.]]
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[[Category: K37s and f69n mutation]]
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[[Category: Mutant pcdhfr inhibitor complex]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tmp/nadph ligand]]

Revision as of 15:48, 19 June 2013

Template:STRUCTURE 4g8z

Contents

pcDHFR K37S/F69N double mutant TMP NADPH ternary complex

Template:ABSTRACT PUBMED 23545530

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4g8z is a 1 chain structure with sequence from Pneumocystis jirovecii. Full crystallographic information is available from OCA.

Reference

  • Cody V, Pace J, Queener SF, Adair OO, Gangjee A. Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. Antimicrob Agents Chemother. 2013 Jun;57(6):2669-77. doi: 10.1128/AAC.00172-13., Epub 2013 Apr 1. PMID:23545530 doi:10.1128/AAC.00172-13

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OCA

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