3df0
From Proteopedia
(Difference between revisions)
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| - | [[Image:3df0.png|left|200px]] | ||
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{{STRUCTURE_3df0| PDB=3df0 | SCENE= }} | {{STRUCTURE_3df0| PDB=3df0 | SCENE= }} | ||
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===Calcium-dependent complex between m-calpain and calpastatin=== | ===Calcium-dependent complex between m-calpain and calpastatin=== | ||
| + | {{ABSTRACT_PUBMED_19020622}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CAN2_RAT CAN2_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. [[http://www.uniprot.org/uniprot/ICAL_RAT ICAL_RAT]] Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. [[http://www.uniprot.org/uniprot/CPNS1_RAT CPNS1_RAT]] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019020622</ref>< | + | <ref group="xtra">PMID:019020622</ref><references group="xtra"/><references/> |
[[Category: Calpain-2]] | [[Category: Calpain-2]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
Revision as of 12:41, 3 July 2013
Contents |
Calcium-dependent complex between m-calpain and calpastatin
Template:ABSTRACT PUBMED 19020622
Function
[CAN2_RAT] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. [ICAL_RAT] Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. [CPNS1_RAT] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
About this Structure
3df0 is a 3 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
See Also
Reference
- Moldoveanu T, Gehring K, Green DR. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature. 2008 Nov 20;456(7220):404-8. PMID:19020622 doi:10.1038/nature07353
