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4fhb
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4fhb| PDB=4fhb | SCENE= }} | {{STRUCTURE_4fhb| PDB=4fhb | SCENE= }} | ||
===Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)=== | ===Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)=== | ||
| + | {{ABSTRACT_PUBMED_23911607}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4fhb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHB OCA]. | [[4fhb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHB OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023911607</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
Revision as of 06:31, 14 August 2013
Contents |
Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)
Template:ABSTRACT PUBMED 23911607
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
4fhb is a 2 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.
See Also
Reference
- Oyen D, Wechselberger R, Srinivasan V, Steyaert J, Barlow JN. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim Biophys Acta. 2013 Jul 31. pii: S1570-9639(13)00282-3. doi:, 10.1016/j.bbapap.2013.07.010. PMID:23911607 doi:10.1016/j.bbapap.2013.07.010
