This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3k74
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3k74.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3k74| PDB=3k74 | SCENE= }} | {{STRUCTURE_3k74| PDB=3k74 | SCENE= }} | ||
| - | |||
===Disruption of protein dynamics by an allosteric effector antibody=== | ===Disruption of protein dynamics by an allosteric effector antibody=== | ||
| + | {{ABSTRACT_PUBMED_21238460}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021238460</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021238460</ref><references group="xtra"/><references/> |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
Revision as of 08:45, 4 September 2013
Contents |
Disruption of protein dynamics by an allosteric effector antibody
Template:ABSTRACT PUBMED 21238460
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3k74 is a 2 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.
See Also
Reference
- Oyen D, Srinivasan V, Steyaert J, Barlow JN. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J Mol Biol. 2011 Mar 18;407(1):138-48. Epub 2011 Jan 14. PMID:21238460 doi:10.1016/j.jmb.2011.01.017
