2fzi

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[[Image:2fzi.png|left|200px]]
 
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{{STRUCTURE_2fzi| PDB=2fzi | SCENE= }}
{{STRUCTURE_2fzi| PDB=2fzi | SCENE= }}
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===New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives===
===New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives===
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{{ABSTRACT_PUBMED_17019704}}
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{{ABSTRACT_PUBMED_17019704}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
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[[2fzi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZI OCA].
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[[2fzi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZI OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017019704</ref><references group="xtra"/>
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<ref group="xtra">PMID:017019704</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Pneumocystis carinii]]
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[[Category: Pneca]]
[[Category: Chisum, K.]]
[[Category: Chisum, K.]]
[[Category: Cody, V.]]
[[Category: Cody, V.]]

Revision as of 11:33, 20 November 2013

Template:STRUCTURE 2fzi

Contents

New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

Template:ABSTRACT PUBMED 17019704

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

2fzi is a 1 chain structure with sequence from Pneca. Full crystallographic information is available from OCA.

See Also

Reference

  • Cody V, Pace J, Chisum K, Rosowsky A. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins. 2006 Dec 1;65(4):959-69. PMID:17019704 doi:10.1002/prot.21131

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OCA

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