3i8a

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[[Image:3i8a.png|left|200px]]
 
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{{STRUCTURE_3i8a| PDB=3i8a | SCENE= }}
{{STRUCTURE_3i8a| PDB=3i8a | SCENE= }}
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===Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)===
===Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)===
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{{ABSTRACT_PUBMED_20026215}}
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{{ABSTRACT_PUBMED_20026215}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
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[[3i8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8A OCA].
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[[3i8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8A OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020026215</ref><references group="xtra"/>
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<ref group="xtra">PMID:020026215</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Staphylococcus aureus]]
 
[[Category: Anderson, A C.]]
[[Category: Anderson, A C.]]
[[Category: Frey, K M.]]
[[Category: Frey, K M.]]
[[Category: Lombardo, M N.]]
[[Category: Lombardo, M N.]]
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[[Category: Nadp]]
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[[Category: Nadph]]
[[Category: One-carbon metabolism]]
[[Category: One-carbon metabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 11:44, 20 November 2013

Template:STRUCTURE 3i8a

Contents

Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Template:ABSTRACT PUBMED 20026215

Function

[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3i8a is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.

See Also

Reference

  • Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J Struct Biol. 2010 Apr;170(1):93-7. Epub 2009 Dec 21. PMID:20026215 doi:10.1016/j.jsb.2009.12.011

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