3dau

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[[Image:3dau.png|left|200px]]
 
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{{STRUCTURE_3dau| PDB=3dau | SCENE= }}
{{STRUCTURE_3dau| PDB=3dau | SCENE= }}
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===Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase===
===Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase===
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{{ABSTRACT_PUBMED_19374017}}
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{{ABSTRACT_PUBMED_19374017}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
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[[3dau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAU OCA].
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[[3dau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAU OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019374017</ref><references group="xtra"/>
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<ref group="xtra">PMID:019374017</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli]]
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[[Category: Ecoli]]
[[Category: Bennett, B C.]]
[[Category: Bennett, B C.]]
[[Category: Dealwis, C G.]]
[[Category: Dealwis, C G.]]

Revision as of 11:57, 20 November 2013

Template:STRUCTURE 3dau

Contents

Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase

Template:ABSTRACT PUBMED 19374017

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3dau is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

See Also

Reference

  • Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. PMID:19374017

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