This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3fqf
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3fqf.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3fqf| PDB=3fqf | SCENE= }} | {{STRUCTURE_3fqf| PDB=3fqf | SCENE= }} | ||
| - | |||
===Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)=== | ===Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)=== | ||
| + | {{ABSTRACT_PUBMED_19249312}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/Q2YY41_STAAB Q2YY41_STAAB]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3fqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3fqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staab Staab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQF OCA]. |
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019249312</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019249312</ref><references group="xtra"/><references/> |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: | + | [[Category: Staab]] |
[[Category: Anderson, A C.]] | [[Category: Anderson, A C.]] | ||
[[Category: Frey, K M.]] | [[Category: Frey, K M.]] | ||
Revision as of 08:25, 27 November 2013
Contents |
Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)
Template:ABSTRACT PUBMED 19249312
Function
[Q2YY41_STAAB] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
About this Structure
3fqf is a 1 chain structure with sequence from Staab. Full crystallographic information is available from OCA.
See Also
Reference
- Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J Mol Biol. 2009 Apr 17;387(5):1298-308. Epub 2009 Feb 26. PMID:19249312 doi:10.1016/j.jmb.2009.02.045
