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4mr0

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4mr0| PDB=4mr0 | SCENE= }}
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===Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae===
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{{ABSTRACT_PUBMED_24321492}}
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The entry 4mr0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PFBA_STRR6 PFBA_STRR6]] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.
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Authors: Ponnuraj, K., Beulin, J.D.S.
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==About this Structure==
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[[4mr0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR0 OCA].
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Description: Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae
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==Reference==
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<ref group="xtra">PMID:024321492</ref><references group="xtra"/><references/>
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[[Category: Beulin, D S.J.]]
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[[Category: Ponnuraj, K.]]
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[[Category: Adhesion]]
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[[Category: Cell adhesion]]
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[[Category: Fibronectin]]
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[[Category: Plasimin and fibronectin-binding protein]]
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[[Category: Plasminogen]]
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[[Category: Surface protein]]

Revision as of 11:10, 5 February 2014

Template:STRUCTURE 4mr0

Contents

Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae

Template:ABSTRACT PUBMED 24321492

Function

[PFBA_STRR6] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.

About this Structure

4mr0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Beulin DS, Yamaguchi M, Kawabata S, Ponnuraj K. Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae, provides hints into its interaction with fibronectin. Int J Biol Macromol. 2013 Dec 7;64C:168-173. doi: 10.1016/j.ijbiomac.2013.11.035. PMID:24321492 doi:http://dx.doi.org/10.1016/j.ijbiomac.2013.11.035

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OCA

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