Fatty acid synthase

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Line 13: Line 13:
[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
 +
[[4bjd]], [[4bje]], [[4bjf]], [[4bjg]] – MtFAS I – Cryo-EM<br />
 +
[[3zen]], [[4b3y]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
[[1xkt]] – hFAS thioesterase domain – human<br />
[[1xkt]] – hFAS thioesterase domain – human<br />
[[2jfd]] – hFAS MAT domain<br />
[[2jfd]] – hFAS MAT domain<br />
Line 41: Line 43:
[[2uvb]] – TlFAS α subunits + NADP<BR />
[[2uvb]] – TlFAS α subunits + NADP<BR />
[[2wat]] – yFAS α subunit + CoA<br />
[[2wat]] – yFAS α subunit + CoA<br />
-
[[2vzp]] – pFAS + NADP<BR />
+
[[2vz9]] – pFAS + NADP<BR />
'''FAS complex with protein'''
'''FAS complex with protein'''
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'''FAS complex with inhibitor'''
'''FAS complex with inhibitor'''
-
[[2vkz]] - yFAS α+β subunits + cerulenin
+
[[2vkz]] - yFAS α+β subunits + cerulenin<br />
 +
[[2px6]] – hFAS thioesterase domain + orlistat<br />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:46, 5 March 2014

Template:STRUCTURE 3tjm

Fatty acid synthase (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).

3D structures of fatty acid synthase

Updated on 05-March-2014

1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
4bjd, 4bje, 4bjf, 4bjg – MtFAS I – Cryo-EM
3zen, 4b3y – FAS – Mycobacterium smegmatis – Cryo-EM
1xkt – hFAS thioesterase domain – human
2jfd – hFAS MAT domain
3hhd - hFAS KS-MAT domain
2cf2, 2vz8 – pFAS – pig
2uv8, 3hmj – yFAS α+β subunits - yeast
2pff, 2was – yFAS α subunit
2uv9 – TlFAS α subunits – Thermomyces lanuginosus
2uva – TlFAS β subunits
2png – FAS ACP domain – rat
1t8k – EcFAS ACP domain - Escherichia coli
2k92, 2k93, 2k94 - EcFAS ACP domain – NMR

FAS complex with fatty acid

1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
3hem - MtFAS CmaA1 + dioctylamine
3tjm – hFAS thioesterase domain + fatty acid
2fae – EcFAS ACP domain + decanethioate
2fad – EcFAS ACP domain + heptanthioate

FAS complex with reactants

2jfk – hFAS + malonyl CoA
2uvc – TlFAS β subunits + NADP
2uvb – TlFAS α subunits + NADP
2wat – yFAS α subunit + CoA
2vz9 – pFAS + NADP

FAS complex with protein

2fhs – EcFAS ACP domain + enoyl-ACP reductase
3ejb - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme
3ejb, 3eje - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid
2cg5 - hFAS ACP domain + AASD-PPT

FAS complex with inhibitor

2vkz - yFAS α+β subunits + cerulenin
2px6 – hFAS thioesterase domain + orlistat

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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