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2e49
From Proteopedia
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{{STRUCTURE_2e49| PDB=2e49 | SCENE= }} | {{STRUCTURE_2e49| PDB=2e49 | SCENE= }} | ||
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===Crystal Structure of Human D-Amino Acid Oxidase in Complex with Imino-Serine=== | ===Crystal Structure of Human D-Amino Acid Oxidase in Complex with Imino-Serine=== | ||
| + | {{ABSTRACT_PUBMED_17303072}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref> | |
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==About this Structure== | ==About this Structure== | ||
[[2e49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E49 OCA]. | [[2e49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E49 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Amino acid oxidase|Amino acid oxidase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017303072</ref><references group="xtra"/> | + | <ref group="xtra">PMID:017303072</ref><references group="xtra"/><references/> |
[[Category: D-amino-acid oxidase]] | [[Category: D-amino-acid oxidase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 08:34, 23 April 2014
Contents |
Crystal Structure of Human D-Amino Acid Oxidase in Complex with Imino-Serine
Template:ABSTRACT PUBMED 17303072
Function
[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]
About this Structure
2e49 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181
- ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181
