User:Brenton Horne/sandbox
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<Structure load='4FYQ' size='350' frame='true' align='right' caption='The structure of human aminopeptidase N (PDB code [http://www.rcsb.org/pdb/explore/explore.do?structureId=4FYQ 4FYQ])' scene='Insert optional scene name here' /> | <Structure load='4FYQ' size='350' frame='true' align='right' caption='The structure of human aminopeptidase N (PDB code [http://www.rcsb.org/pdb/explore/explore.do?structureId=4FYQ 4FYQ])' scene='Insert optional scene name here' /> | ||
| - | Aminopeptidase N is a zinc-dependent integral ectopeptidase that cleaves neutral amino acids from the N-terminal of peptides.<ref name = cancer>PMID: 21619485</ref> It has been implicated in coronovirus invasion of cells of the respiratory tract and | + | '''Aminopeptidase N''' (APN; CD13)is a zinc-dependent integral ectopeptidase that cleaves neutral amino acids from the N-terminal of peptides.<ref name = cancer>PMID: 21619485</ref> It has been implicated in coronovirus invasion of cells of the respiratory tract and numerous cancers.<ref name = cancer/><ref>PMID: 24762977</ref> Its expression in cancer cells has been associated with more aggressive phenotypes and a role for it has been determined in: breast cancer, colon cancer, stomach cancer, non-small cell lung cancer, kidney cancer, ovarian cancer, pancreatic cancer and thryoid cancer.<ref name = cancer/> It is also an enkephalinase, that is, it is an enzyme involved in the degradation of enkephalins, such as met-enkephalin and leu-enkephalin.<ref>PMID: 18855623</ref> Additional roles in immunity have also been proposed and the potential use of APN inhibitors has been proposed as a potential drug therapy for inflammatory bowel disease.<ref>PMID: 18508466</ref> |
| - | + | ||
| - | |||
| - | == Disease == | ||
| - | |||
| - | == Relevance == | ||
| - | |||
| - | == Structural highlights == | ||
| - | |||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| - | |||
| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 03:34, 7 May 2014
|
Aminopeptidase N (APN; CD13)is a zinc-dependent integral ectopeptidase that cleaves neutral amino acids from the N-terminal of peptides.[1] It has been implicated in coronovirus invasion of cells of the respiratory tract and numerous cancers.[1][2] Its expression in cancer cells has been associated with more aggressive phenotypes and a role for it has been determined in: breast cancer, colon cancer, stomach cancer, non-small cell lung cancer, kidney cancer, ovarian cancer, pancreatic cancer and thryoid cancer.[1] It is also an enkephalinase, that is, it is an enzyme involved in the degradation of enkephalins, such as met-enkephalin and leu-enkephalin.[3] Additional roles in immunity have also been proposed and the potential use of APN inhibitors has been proposed as a potential drug therapy for inflammatory bowel disease.[4]
References
- ↑ 1.0 1.1 1.2 Su L, Fang H, Xu W. Aminopeptidase N (EC 3.4.11.2) inhibitors (2006 - 2010): a patent review. Expert Opin Ther Pat. 2011 Aug;21(8):1241-65. doi: 10.1517/13543776.2011.587002. , Epub 2011 May 28. PMID:21619485 doi:http://dx.doi.org/10.1517/13543776.2011.587002
- ↑ Bosch BJ, Smits SL, Haagmans BL. Membrane ectopeptidases targeted by human coronaviruses. Curr Opin Virol. 2014 Apr 21;6C:55-60. doi: 10.1016/j.coviro.2014.03.011. PMID:24762977 doi:http://dx.doi.org/10.1016/j.coviro.2014.03.011
- ↑ Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008 Oct;9(10):887-94. PMID:18855623
- ↑ Bank U, Bohr UR, Reinhold D, Lendeckel U, Ansorge S, Malfertheiner P, Tager M. Inflammatory bowel diseases: multiple benefits from therapy with dipeptidyl- and alanyl-aminopeptidase inhibitors. Front Biosci. 2008 May 1;13:3699-713. PMID:18508466
