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3t7v

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[[Image:3t7v.png|left|200px]]
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==Crystal structure of methylornithine synthase (PylB)==
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<StructureSection load='3t7v' size='340' side='right' caption='[[3t7v]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3t7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7V FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MD0:5-AMINO-D-ISOLEUCINE'>MD0</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r30|1r30]], [[3ciw|3ciw]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mbar_A0838 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2208 Methanosarcina barkeri])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin_synthase Biotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.6 2.8.1.6] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7v RCSB], [http://www.ebi.ac.uk/pdbsum/3t7v PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Made by the barrel load: The biosynthetic pathway of the recently discovered 22nd amino acid, pyrrolysine, starts with an isomerization of lysine to methylornithine, catalyzed by PylB. The X-ray crystal structure of PylB is determined and shows it has a TIM barrel fold. The sealed central cavity contains a [4Fe-4S] cluster, S-adenosylmethionine (SAM), and methylornithine, whose 2R,3R configuration could be confirmed. The data suggest a fragmentation-recombination mechanism via a glycyl radical intermediate.
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<!--
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Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis.,Quitterer F, List A, Eisenreich W, Bacher A, Groll M Angew Chem Int Ed Engl. 2011 Nov 16. doi: 10.1002/anie.201106765. PMID:22095926<ref>PMID:22095926</ref>
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The line below this paragraph, containing "STRUCTURE_3t7v", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3t7v| PDB=3t7v | SCENE= }}
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===Crystal structure of methylornithine synthase (PylB)===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22095926}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22095926 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22095926}}
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==About this Structure==
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[[3t7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7V OCA].
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==Reference==
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<ref group="xtra">PMID:022095926</ref><references group="xtra"/>
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[[Category: Biotin synthase]]
[[Category: Biotin synthase]]
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]

Revision as of 06:41, 5 June 2014

Crystal structure of methylornithine synthase (PylB)

3t7v, resolution 1.50Å

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