Albumin
From Proteopedia
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The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments. | The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments. | ||
</StructureSection> | </StructureSection> | ||
| - | __NOTOC__ | ||
== 3D Structures of albumin == | == 3D Structures of albumin == | ||
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[[2vdb]] - hSA + peptostreptococcal albumin-binding protein GA module + naproxen | [[2vdb]] - hSA + peptostreptococcal albumin-binding protein GA module + naproxen | ||
| - | ===Other serum | + | ===Other serum albumins=== |
[[3v03]], [[4f5s]] - bSA – bovine<br /> | [[3v03]], [[4f5s]] - bSA – bovine<br /> | ||
Revision as of 08:52, 14 August 2014
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Contents |
3D Structures of albumin
Updated on 14-August-2014
Human serum albumin
1e78, 1bm0, 1ao6, 1uor, 4g03, 4g04, 4k2c - hSA – human
Human serum albumin binary complex
2ydf – hSA + iophenoxic acid
2xvq, 2xvu, 2xw0, 2xw1 - hSA + dansyl derivative
3lu6, 3ju7, 3lu8, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf , 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 3lu7, 4l8u, 4l9q, 4la0, 4lb2, 4lb9 – hSA + drug
4iw1, 4iw2 – hSA + monosaccharide
3jqz – hSA + lidocaine
3jry - hSA + sulfate
4emx – has + Cl
1n5u - hSA + heme
3a73 - hSA + prostaglandin
2vuf, 2vue - hSA + bilirubin derivative
1gni, 1gnj, 1e7h, 1e7e, 1e7f, 1e7i, 1bke, 1bj5, 3tdl, 4e99 - hSA + fatty acid
1hk1 - hSA + thiroxine
2hk2, 1hk3, 1hk2 - hSA (mutant) + thiroxine
1e7a, 1e7b - hSA + general anesthetic
1tf0 - hSA + peptostreptococcal albumin-binding protein GA module
2esg - hSA + immunoglobulin A1
1ysx - hSA + anti-apoptotic ligand – NMR
4hgk, 4hgm – hSA + shark antibody
Human serum albumin ternary complex
2xsi, 2xvv, 2xvw – hSA + dansyl derivative + myristic acid
3cx9 - hSA + lysophospholipid + myristic acid
1e7g - hSA + fatty acid + myristic acid
1h9z, 1ha2 - hSA + warfarine + myristic acid
1e7c - hSA + general anesthetic + myristic acid
1hk4 - hSA + thiroxine + myristic acid
1hk5 - hSA (mutant) + thiroxine + myristic acid
1o9x - hSA + hemin + myristic acid
3uiv - hSA + amantadine + myristic acid
3b9l - hSA + AZT + myristic acid
2i2z - hSA + aspirin + myristic acid
2i30 - hSA + salicylic acid + myristic acid
3b9m - hSA + AZT + salicylic acid + myristic acid
2vdb - hSA + peptostreptococcal albumin-binding protein GA module + naproxen
Other serum albumins
3v03, 4f5s - bSA – bovine
3v08, 4f5t, 4f5u – hoSA – horse
3v09, 4f5u – SA – rabbit
3vvj – SA – emu
4j2v – hoSA + diiodosalicilate
4jk4 – bSA + diiodosalicilate
Albumin
1s6d – Alb 8 – sunflower – NMR
1wba – Alb 1 – winged bean
1p8b – Alb 1 – pea
1psy – Alb – castor bean - NMR
3lp9 – Alb hemopexin domain – Lathyrus sativus
2lvf – Alb – Brazil nut
References
- ↑ Liu Y, Chen M, Luo Z, Lin J, Song L. Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride. J Biomol Struct Dyn. 2012 Oct 17. PMID:23072300 doi:10.1080/07391102.2012.726532
