Fatty acid synthase
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | |||
| + | ===FAS=== | ||
[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | [[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | ||
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[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR | [[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR | ||
| - | + | ===FAS complex with fatty acid=== | |
[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br /> | [[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br /> | ||
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[[2fad]] – EcFAS ACP domain + heptanthioate | [[2fad]] – EcFAS ACP domain + heptanthioate | ||
| - | + | ===FAS complex with reactants=== | |
[[2jfk]] – hFAS + malonyl CoA<br /> | [[2jfk]] – hFAS + malonyl CoA<br /> | ||
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[[2vz9]] – pFAS + NADP<BR /> | [[2vz9]] – pFAS + NADP<BR /> | ||
| - | + | ===FAS complex with protein=== | |
[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br /> | [[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br /> | ||
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[[2cg5]] - hFAS ACP domain + AASD-PPT | [[2cg5]] - hFAS ACP domain + AASD-PPT | ||
| - | + | ===FAS complex with inhibitor=== | |
[[2vkz]] - yFAS α+β subunits + cerulenin<br /> | [[2vkz]] - yFAS α+β subunits + cerulenin<br /> | ||
Revision as of 08:09, 18 August 2014
Fatty acid synthase (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).
Contents |
3D structures of fatty acid synthase
Updated on 18-August-2014
FAS
1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
4bjd, 4bje, 4bjf, 4bjg – MtFAS I – Cryo-EM
3zen, 4b3y – FAS – Mycobacterium smegmatis – Cryo-EM
1xkt – hFAS thioesterase domain – human
2jfd – hFAS MAT domain
3hhd - hFAS KS-MAT domain
2cf2, 2vz8 – pFAS – pig
2uv8, 3hmj – yFAS α+β subunits - yeast
2pff, 2was – yFAS α subunit
2uv9 – TlFAS α subunits – Thermomyces lanuginosus
2uva – TlFAS β subunits
2png – FAS ACP domain – rat
1t8k – EcFAS ACP domain - Escherichia coli
2k92, 2k93, 2k94 - EcFAS ACP domain – NMR
FAS complex with fatty acid
1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
3hem - MtFAS CmaA1 + dioctylamine
3tjm – hFAS thioesterase domain + fatty acid
2fae – EcFAS ACP domain + decanethioate
2fad – EcFAS ACP domain + heptanthioate
FAS complex with reactants
2jfk – hFAS + malonyl CoA
2uvc – TlFAS β subunits + NADP
2uvb – TlFAS α subunits + NADP
2wat – yFAS α subunit + CoA
2vz9 – pFAS + NADP
FAS complex with protein
2fhs – EcFAS ACP domain + enoyl-ACP reductase
3ejb - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme
3ejb, 3eje - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid
2cg5 - hFAS ACP domain + AASD-PPT
FAS complex with inhibitor
2vkz - yFAS α+β subunits + cerulenin
2px6 – hFAS thioesterase domain + orlistat
