GTP-binding protein
From Proteopedia
| Line 24: | Line 24: | ||
| - | '''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases | + | '''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. See details on GTP-binding protein LpeD in [[LepA]]. |
{{Template:GPCR3sn6}} | {{Template:GPCR3sn6}} | ||
| - | <br /> | ||
| - | <br /> | ||
| - | <br /> | ||
| - | <br /> | ||
| - | <br /> | ||
== 3D Structures of GTP-binding protein == | == 3D Structures of GTP-binding protein == | ||
Revision as of 09:49, 27 August 2014
GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. See details on GTP-binding protein LpeD in LepA.
| |||||||||||
| |||||||||||
3D Structures of GTP-binding protein
Updated on 27-August-2014
GTP-binding protein
3r7w, 4arz – yGtr1 + Gtr2 – yeast
2eki – hGBP TGS domain – NMR - human
3kxk, 3kxl – SsHflx (mutant) - Sulfolobus solfataricus
2qtf – SsHflx
1ega – EcERA – Escherichia coli
2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM
3cb4 - EcLepA
2ywe – AaLepA
1sul – BsYsxC - Bacillus subtilis
2dwq – TtYchF
1udx – TtObg
1wxq – GBP – Pyrococcus horikoshii
1yr6 - PaGBP – Pyrococcus abyssi
1ni3 – YchF – Schizosaccharomyces pombe
GTP-binding protein complex with nucleotide
2nzj – hRem1 + GDP
3cbq – hRem2 + GDP
3q85 – hRem2 G domain + GTP analog
2cjw, 2ht6, 2g3y – hGem G domain + GDP
4aii - rRem2 G domain + GDP - rat
2ohf – hOla1 + AMP-PCP
1xtq – hRheB + GDP
1xts - hRheB + GTP
1xtr - hRheB + GPPNHP
3sea - hRheB + GDP + GNP
1e0a – hGBP (mutant) + GIP
2b8w, 2d4h – hGBP N terminal + GMP
2b92 - hGBP N terminal + GDP
2bc9 - hGBP N terminal + GPPNHP
1yr7, 1yr8 – PaGBP + GTP
1yr9, 1yra, 1yrb, 2oxr – PaGBP + GDP
3kxi, 2qth – SsHflx + GDP
3ieu – EcERA + GDP
3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus
1x1l – TtERA + RNA – Cryo EM
2ywf – AaLepA + GMP-PNP
2ywg - AaLepA + GTP
2ywh - AaLepA + GDP
1yzn – yPt1 + GPPNHP
1ky2 – yPt7 + GPPNHP
1ky3 – yPt7 + GDP
3rwm, 3rwo – yPt32 + GPPNHP
1ek0 – yPt51 + GPPNHP
2hjg, 4dcs, 4dct, 4dcu, 4dcv – BsEngA + GDP
1svi – BsYsxC + GDP
1svw – BsYsxC + GMPPNP
1lnz – BsObg + GTP
2dby – TtYchF + GDP
1wf3 – Tt1341 + GNP
2gao - hSar1A + GDP
2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
2fmx - ChSar1B + GDP
GTP-binding protein complex with protein
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
3cue – yPt1 + transport protein subunits
2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
3cpj – yPt31 + Rab GDP-dissociation inhibitor
1m2o – ySar1 + protein transport protein sec23
3syn – BsFlhf + ATP-binding protein
G protein bound to a G protein-coupled receptor
3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated G protein-coupled receptor in a complex with its G protein.
Ras-related GTP-binding protein
3llu – hC nucleotide-binding domain
Ras-related GTP-binding protein complex with nucleotide
2l0x – rRheb + GDP
2gjs – hRad1 + GDP
3q72, 3q7p, 3q7q – hRad G-domain + GTP analog
2dpx – hRad GTPase domain
2gf0 – hDiRas1 + GDP
2erx – hDiRas2 + Pi + GDP
1x3s – hRab-18 + GPPNHP
1yu9 - hRab-4A + GPPNHP
2atx – hTc10 + GPPNHP
1g16 – ySec4 + GDP
1g17 - ySec4 + GIP
Ras-related GTP-binding protein complex with protein
3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
3brw - hRap-1B + Rap GTPase-activating protein
1z0k – hRab-4 + rabenosyn-5
3tw8 – hRab-1C + DENND
Interferon-induced GTP-binding protein
3ljb – hMx1 stalk region
3szr – hMx1 residues 33-662
3zys – hMx1 + dynamin-1
Rho-related GTP-binding protein
2j1l – hRhoD
Rho-related GTP-binding protein complex with nucleotide
2cls – hRho6 + GTP
2fv8 - hRhoB + GDP
2gcn – hRhoC + GDP
2gco – hRhoC + GPPNHP
1z2c - hRhoC (mutant) + GMPPNP
2gcp – hRhoC + GSP
1m7b - hRhoE + GTP
1gwn - RhoE + GTP - mouse
1a4r - hCdc42 (mutant) + GDP
1an0 - hCdc42 + GDP
2qrz - hCdc42 + GCP
Rho-related GTP-binding protein complex with protein
2v55 – hRhoE + Rho-associated protein kinase
3q3j – hRho6 + plexin-A2 nucleotide-binding domain
2rex – hRho6 + plexin-B1
1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
3a58 – yRho1 (mutant) + exocyst complex component Sec3
1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
2kb0 - hCdc42 (mutant)
1kz7 - hCdc42 + guanine nucleotide exchange factor
1kzg - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)
2dfk – hCdc42 + collybistin II
2wm9, 2wmn, 2wmo - hCdc42 + DOCK9
3eg5 - hCdc42 + protein diaphanous homolog 1 + GMPPNP
3gcg - hCdc42 + MAP
3n3v - hCdc42 + AMP-protein transferase
1nf3 - hCdc42 + Par6
2ase - hCdc42 (mutant) - NMR
1ki1 – hCdc42 + intersectin long form
1ees – hCdc42 + MapK3 peptide - NMR
1doa - hCdc42 + GDP-dissociation inhibitor
2ngr – hCdc42 + GTPase-activating protein C terminal + GDP
1am4 – hCdc42 + GTPase-activating protein rhoGAP + GNP
1grn – hCdc42 + GTPase-activating protein rhoGAP + GDP
1cf4 – hCdc42 (mutant) + ACK GTPase-binding domain + GNP - NMR
1cee – hCdc42 + WASP GTPase-binding domain + GCP - NMR
2odb – hCdc42 + PAK6 CRIB domain + GCP
3qbv – hCdc42 (mutant) + intersectin + GDP
4did – hCdc42 + inositol phosphate phosphatase + GDP
1cf4 – hCdc42 (mutant) + dedicator of cytokinesis protein 8
4itr – hCdc42 + AMP-protein transferase + GDP + AMP
Rac-like GTP-binding protein
2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
3bwd – AtArac6
2nty – AtArac5 + prone8
2j0v – AtArac7 (mutant)
Rab-related GTP-binding protein
2ys8 – hRabJ DNAJ domain – NMR
Flagella-associated GTP-binding protein
2px0 – BsFlhF + GMP-PNP
2px3 – BsFlhF + GTP
GTP-binding protein Ran
Ran binary complex
3gj0 – hRan + GDP
1i2m – hRan + regulator of chromosome condensation 1
1byu – Ran + GDP - dog
1qg2, 1qg4, 3ran – dRan (mutant) + GDP
2bku – dRan + importin
Ran ternary complex
1rrp – hRan + Nup358 + GTP analog
1qbk – hRan + karyopherin β2 + GTP analog
1ibr – hRan + importin β1 subunit + GTP analog
3ea5 – hRan (mutant) + importin β1 subunit + GDP
4c0q - hRan (mutant) + importin 12 + GTP
3nc1 – hRan (mutant) + exportin 1 + GTP
3ch5, 3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8 – hRan + Nup153 + GDP
3w3z – dRan + importin β1 subunit + GTP
Ran quaternary complex
3gjx – hRan + snurportin 1 + exportin 1 + GTP
3nby, 3nbz, 3nc0 – hRan (mutant) + snurportin 1 + exportin 1 + GTP
1k5d – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog
1k5g – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP
4gpt, 4gmx, 4hat, 4hb2, 4hb3 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP
4hat, 4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb4 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic
3zjy – hRan (mutant) + importin 13 + EIF-1A + GTP
3a6p – dRan + pre-microRNA + exportin 5 + peptide
3icq – yRan + RNA + exportin T
3m1i – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP
Small GTP-binding protein
2rhd – GBP – Cryptosporidium parvum
1yzq - hRab-6 + GNP
3qq5 – GBP – Thermotoga neapolitana
See Also
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, Jaime Prilusky
