3bw8

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[[Image:3bw8.png|left|200px]]
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==Crystal structure of the Clostridium limosum C3 exoenzyme==
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<StructureSection load='3bw8' size='340' side='right' caption='[[3bw8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bw8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_limosum Clostridium limosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BW8 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ojq|1ojq]], [[1ojz|1ojz]], [[1gzf|1gzf]], [[1gze|1gze]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">c3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1536 Clostridium limosum])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bw8 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/3bw8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C3-like toxins ADP-ribosylate and inactivate Rho GTPases. Seven C3-like ADP-ribosyltransferases produced by Clostridium botulinum, Clostridium limosum, Bacillus cereus and Staphylococcus aureus were identified and two representatives--C3bot from C. botulinum and C3stau2 from S. aureus--were crystallized. Here we present the 1.8A structure of C. limosum C3 transferase C3lim and compare it to the structures of other family members. In contrast to the structure of apo-C3bot, the canonical ADP-ribosylating turn turn motif is observed in a primed conformation, ready for NAD binding. This suggests an impact on the binding mode of NAD and on the transferase reaction. The crystal structure explains why auto-ADP-ribosylation of C3lim at Arg41 interferes with the ADP-ribosyltransferase activity of the toxin.
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{{STRUCTURE_3bw8| PDB=3bw8 | SCENE= }}
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Crystal structure of the Clostridium limosum C3 exoenzyme.,Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A, Aktories K FEBS Lett. 2008 Apr 2;582(7):1032-6. Epub 2008 Mar 4. PMID:18325337<ref>PMID:18325337</ref>
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===Crystal structure of the Clostridium limosum C3 exoenzyme===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18325337}}
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==See Also==
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*[[Exoenzyme|Exoenzyme]]
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==About this Structure==
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== References ==
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[[3bw8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_limosum Clostridium limosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BW8 OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018325337</ref><references group="xtra"/>
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[[Category: Clostridium limosum]]
[[Category: Clostridium limosum]]
[[Category: Aktories, K.]]
[[Category: Aktories, K.]]

Revision as of 21:17, 2 October 2014

Crystal structure of the Clostridium limosum C3 exoenzyme

3bw8, resolution 1.80Å

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