Molecular Playground/Insulin

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</StructureSection> For additional details see [[Insulin Structure & Function]].
</StructureSection> For additional details see [[Insulin Structure & Function]].
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==3D structures of insulin==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==3D structures of Insulin (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) ==
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
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[[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]] - hIns A chain + B chain – human<BR />
+
 
-
[[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction<BR />
+
* Insulin
-
[[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
+
 
-
[[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR />
+
** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]] - hIns A chain + B chain – human<BR />
 +
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction<BR />
 +
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
 +
** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR />
[[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
[[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
[[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain<BR />
[[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain<BR />
-
[[1w8p]] - hIns A chain + B chain (mutant) <BR />
+
** [[1w8p]] - hIns A chain + B chain (mutant) <BR />
-
[[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53<BR />
+
** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53<BR />
[[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR />
[[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR />
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[[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br />
+
** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br />
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[[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)<br />
+
** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)<br />
-
[[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR />
+
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR />
-
[[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<BR />
+
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<BR />
[[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine<BR />
[[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine<BR />
-
[[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54<br />
+
** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54<br />
-
[[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54<br />
+
** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54<br />
-
[[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
+
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
-
[[6ins]] – pIns single chain
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** [[6ins]] – pIns single chain
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===Insulin structures using NMR===
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*Insulin structures using NMR
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[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]] - hIns A chain + B chain – NMR<BR />
+
** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]] - hIns A chain + B chain – NMR<BR />
-
[[2hiu]] – apo-hIns A chain + B chain – NMR<BR />
+
** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR />
-
[[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]] - hIns A chain (mutant) + B chain – NMR<BR />
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** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]] - hIns A chain (mutant) + B chain – NMR<BR />
-
[[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]] - hIns A chain + B chain (mutant) – NMR<BR />
+
** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]] - hIns A chain + B chain (mutant) – NMR<BR />
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[[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR />
+
** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR />
[[2l1y]], [[2l1z]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR<br />
[[2l1y]], [[2l1z]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR<br />
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[[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
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** [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
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[[1lkq]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR<BR />
+
** [[1lkq]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR<BR />
-
[[2jv1]] – apo-hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
+
** [[2jv1]] – apo-hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
-
[[2jzq]] - hIns A chain – NMR<BR />
+
** [[2jzq]] - hIns A chain – NMR<BR />
-
[[1ho0]] - hIns B chain (mutant) – NMR<BR />
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** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
-
[[2lwz]] – hIns single chain - NMR<br />
+
** [[2lwz]] – hIns single chain - NMR<br />
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+
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===Insulin complexes===
+
-
[[3brr]] - hIns A chain + B chain + sulfatide<BR />
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* Insulin complexes
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[[1ben]] - hIns A chain + B chain + hydroxybenzamide<BR />
+
-
[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide<BR />
+
-
[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol<BR />
+
-
[[2omg]] - hIns A chain + B chain + urea + cresol<br />
+
-
[[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate<BR />
+
-
[[1jk8]] - hIns B chain peptide + HLA<BR />
+
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[[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol<br />
+
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[[1qiy]] - hIns A chain + B chain residues 25-54 (mutant) + phenol<br />
+
-
[[1qiz]] - hIns A chain + B chain residues 25-54 (mutant) + resorcinol<BR />
+
-
[[1ev3]], [[1ev6]] - hIns A chain residues 87-107 + B chain residues 25-54+ cresol<br />
+
-
[[1evr]] - hIns A chain residues 87-107 + B chain residues 25-54+ resorcinol<BR />
+
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[[3q6e]] - hIns A chain residues 90-110 + B chain residues 25-54+ synthetic receptor<BR />
+
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[[2g54]], [[2g56]] - hIns B chain residues 25-54 + insulin-degrading enzyme<br />
+
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[[2wby]], [[2wc0]] - hIns A chain residues 90-109 + B chain residues 25-54 + insulin-degrading enzyme (mutant)<br />
+
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[[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
+
-
[[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
+
-
[[1mpj]] - pIns A chain + B chain + phenol<br />
+
-
[[2tci]] - pIns A chain + B chain + thiocyanate<BR />
+
-
[[3mth]] - pIns A chain + B chain + methylparaben<BR />
+
-
[[1zei]] - pIns A chain (mutant) + cresol<br />
+
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[[7ins]] - pIns A chain + B chain + clupeine + cresol<br />
+
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[[3w14]] - bIns A chain + B chain + insulin-degrading enzyme + antibody<br />
+
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===Proinsulin===
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** [[3brr]] - hIns A chain + B chain + sulfatide<BR />
 +
** [[1ben]] - hIns A chain + B chain + hydroxybenzamide<BR />
 +
** [[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide<BR />
 +
** [[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol<BR />
 +
** [[2omg]] - hIns A chain + B chain + urea + cresol<br />
 +
** [[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate<BR />
 +
** [[1jk8]] - hIns B chain peptide + HLA<BR />
 +
** [[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol<br />
 +
** [[1qiy]] - hIns A chain + B chain residues 25-54 (mutant) + phenol<br />
 +
** [[1qiz]] - hIns A chain + B chain residues 25-54 (mutant) + resorcinol<BR />
 +
** [[1ev3]], [[1ev6]] - hIns A chain residues 87-107 + B chain residues 25-54+ cresol<br />
 +
** [[1evr]] - hIns A chain residues 87-107 + B chain residues 25-54+ resorcinol<BR />
 +
** [[3q6e]] - hIns A chain residues 90-110 + B chain residues 25-54+ synthetic receptor<BR />
 +
** [[2g54]], [[2g56]] - hIns B chain residues 25-54 + insulin-degrading enzyme<br />
 +
** [[2wby]], [[2wc0]] - hIns A chain residues 90-109 + B chain residues 25-54 + insulin-degrading enzyme (mutant)<br />
 +
** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
 +
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
 +
** [[1mpj]] - pIns A chain + B chain + phenol<br />
 +
** [[2tci]] - pIns A chain + B chain + thiocyanate<BR />
 +
** [[3mth]] - pIns A chain + B chain + methylparaben<BR />
 +
** [[1zei]] - pIns A chain (mutant) + cresol<br />
 +
** [[7ins]] - pIns A chain + B chain + clupeine + cresol<br />
 +
** [[3w14]] - bIns A chain + B chain + insulin-degrading enzyme + antibody<br />
-
[[2kqp]] – hPIns A chain – NMR<BR />
+
* Proinsulin
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[[1t0c]] - hPIns A chain residues 57-87 – NMR<BR />
+
-
[[1iog]], [[1ioh]], [[1sjt]] - hPIns A chain (mutant) + B chain (mutant) – NMR<BR />
+
-
[[1efe]] – mini-hPIns<BR />
+
-
[[1sju]] - mini-hPIns (mutant)
+
-
===Despeptide insulin===
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** [[2kqp]] – hPIns A chain – NMR<BR />
 +
** [[1t0c]] - hPIns A chain residues 57-87 – NMR<BR />
 +
** [[1iog]], [[1ioh]], [[1sjt]] - hPIns A chain (mutant) + B chain (mutant) – NMR<BR />
 +
** [[1efe]] – mini-hPIns<BR />
 +
** [[1sju]] - mini-hPIns (mutant)
-
[[2ceu]] – DPI – yeast<BR />
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* Despeptide insulin
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[[1sdb]] - pDPI A chain + B chain<BR />
+
-
[[1pid]] - bDPI A chain + B chain<BR />
+
-
[[1his]] - hDPI A chain + B chain]] - NMR<BR />
+
-
[[1htv]] – hDTRI A chain + B chain<BR />
+
-
[[1dei]] – pDHPI A chain (mutant) + B chain (mutant) <BR />
+
-
[[2ins]] – bD-Phe Ins chain A + chain B
+
-
===Leginsulin===
+
** [[2ceu]] – DPI – yeast<BR />
 +
** [[1sdb]] - pDPI A chain + B chain<BR />
 +
** [[1pid]] - bDPI A chain + B chain<BR />
 +
** [[1his]] - hDPI A chain + B chain]] - NMR<BR />
 +
** [[1htv]] – hDTRI A chain + B chain<BR />
 +
** [[1dei]] – pDHPI A chain (mutant) + B chain (mutant) <BR />
 +
** [[2ins]] – bD-Phe Ins chain A + chain B
-
[[1ju8]] – Lins A chain residues 1-37 – legume - NMR<BR />
+
* Leginsulin
 +
** [[1ju8]] – Lins A chain residues 1-37 – legume - NMR<BR />
 +
}}

Revision as of 17:26, 2 November 2014

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.

Human insulin chain A (grey) and chain B (green), 3i40

Drag the structure with the mouse to rotate
For additional details see Insulin Structure & Function.


3D structures of Insulin (Updated on 02-November-2014)

3ir0, 3inc, 3ilg, 3kq6, 3exx, 2r34, 2r35, 2r36, 3tt8 - hIns A chain + B chain + non-Zn metal ion
3fq9, 1xw7, 1rwe, 1jca, 1j73, 4efx - hIns A chain (mutant) + B chain
2wru, 2wrv, 2wrw, 2wrx, 2ws0, 2ws1, 2ws4, 2ws6, 2ws7, 1qj0 - hIns A chain + B chain residues 25-54 (mutant)
2zp6, 1aph, 1bph, 1cph, 1dph, 4e7t, 4e7u, 4e7v, 4idw, 4bs3, 4i5y, 4i5z, 4ihn, 4m4f, 4m4h, 4m4i, 4m4j, 4m4l, 4m4m - bIns A chain + B chain – bovine

2l1y, 2l1z - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR



Additional Resources

For additional information, see: Diabetes & Hypoglycemia

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