Molecular Playground/Insulin

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** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR />
** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR />
-
[[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
+
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
-
[[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain<BR />
+
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain<BR />
** [[1w8p]] - hIns A chain + B chain (mutant) <BR />
** [[1w8p]] - hIns A chain + B chain (mutant) <BR />
** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53<BR />
** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53<BR />
-
[[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR />
+
** [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR />
** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br />
** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br />
** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)<br />
** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)<br />
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR />
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<BR />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<BR />
-
[[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine<BR />
+
** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine<BR />
** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54<br />
** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54<br />
** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54<br />
** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54<br />

Revision as of 17:28, 2 November 2014

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.

Human insulin chain A (grey) and chain B (green), 3i40

Drag the structure with the mouse to rotate
For additional details see Insulin Structure & Function.


3D structures of Insulin (Updated on 02-November-2014)

2l1y, 2l1z - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR



Additional Resources

For additional information, see: Diabetes & Hypoglycemia

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