Molecular Playground/Insulin
From Proteopedia
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* Insulin | * Insulin | ||
| - | ** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]] - hIns A chain + B chain – human<BR /> | + | ** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]] - hIns A chain + B chain – human <BR /> |
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR /> | ** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR /> | ||
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR /> | ** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR /> | ||
** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR /> | ** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR /> | ||
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR /> | ** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR /> | ||
| - | ** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain<BR /> | + | ** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain <BR /> |
** [[1w8p]] - hIns A chain + B chain (mutant) <BR /> | ** [[1w8p]] - hIns A chain + B chain (mutant) <BR /> | ||
| - | ** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53<BR /> | + | ** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53 <BR /> |
** [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR /> | ** [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR /> | ||
** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br /> | ** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br /> | ||
| - | ** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)<br /> | + | ** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) <br /> |
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR /> | ** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR /> | ||
| - | ** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<BR /> | + | ** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR /> |
| - | ** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine<BR /> | + | ** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine <BR /> |
| - | ** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54<br /> | + | ** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54 <br /> |
| - | ** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54<br /> | + | ** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54 <br /> |
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR /> | ** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR /> | ||
** [[6ins]] – pIns single chain | ** [[6ins]] – pIns single chain | ||
| - | *Insulin structures using NMR | + | * Insulin structures using NMR |
** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]] - hIns A chain + B chain – NMR<BR /> | ** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]] - hIns A chain + B chain – NMR<BR /> | ||
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** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]] - hIns A chain + B chain (mutant) – NMR<BR /> | ** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]] - hIns A chain + B chain (mutant) – NMR<BR /> | ||
** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR /> | ** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR /> | ||
| - | [[2l1y]], [[2l1z]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR<br /> | + | ** [[2l1y]], [[2l1z]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR<br /> |
** [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR /> | ** [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR /> | ||
** [[1lkq]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR<BR /> | ** [[1lkq]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR<BR /> | ||
Revision as of 17:31, 2 November 2014
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.
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3D structures of Insulin (Updated on 02-November-2014)
Additional Resources
For additional information, see: Diabetes & Hypoglycemia
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Shelly Livne, Karsten Theis, David Canner, Whitney Stoppel, Alexander Berchansky, Yael Shwartz, Lynmarie K Thompson, Jaime Prilusky
