Isocitrate dehydrogenase

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<StructureSection load='2uxr' size='450' side='right' scene='' caption='Isocitrate dehydrogenase dimer complex with isocitrate, glycerol and Mg+2 ion (green) (PDB code [[2uxr]])'>
<StructureSection load='2uxr' size='450' side='right' scene='' caption='Isocitrate dehydrogenase dimer complex with isocitrate, glycerol and Mg+2 ion (green) (PDB code [[2uxr]])'>
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--[[User:Michal Harel|Michal Harel]] 11:30, 17 June 2012 (IDT)
 
[[Image:1sjs.png|left|200px|thumb|Crystal Structure of Isocitrate dehydrogenase, [[1sjs]]]]
[[Image:1sjs.png|left|200px|thumb|Crystal Structure of Isocitrate dehydrogenase, [[1sjs]]]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Isocitrate dehydrogenase===
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*Isocitrate dehydrogenase
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[[3blx]] – hIDH - yeast<br />
+
**[[3blx]] – hIDH - yeast<br />
-
[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
+
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
-
[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
+
**[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
-
[[2e0c]], [[2dht]] - StIDH – ''Sulfolobus tokodaii''<br />
+
**[[2e0c]], [[2dht]] - StIDH – ''Sulfolobus tokodaii''<br />
-
[[2iv0]] – IDH – ''Archaeoglobus fulgidus''<br />
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**[[2iv0]] – IDH – ''Archaeoglobus fulgidus''<br />
-
[[1zor]] – IDH – ''Thermotoga maritima''<br />
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**[[1zor]] – IDH – ''Thermotoga maritima''<br />
-
[[2b0t]] – IDH – ''Corynebacterium glutamicum''<br />
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**[[2b0t]] – IDH – ''Corynebacterium glutamicum''<br />
-
[[1xgv]], [[1v94]] - ApIDH – ''Aeropyrum pernix''<br />
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**[[1xgv]], [[1v94]] - ApIDH – ''Aeropyrum pernix''<br />
-
[[1pb3]], [[1sjs]], [[6icd]], [[7icd]], [[3icd]] – EcIDH – ''Escherichia coli''<br />
+
**[[1pb3]], [[1sjs]], [[6icd]], [[7icd]], [[3icd]] – EcIDH – ''Escherichia coli''<br />
-
[[1idd]], [[1idf]], [[4icd]] - EcIDH (mutant)<br />
+
**[[1idd]], [[1idf]], [[4icd]] - EcIDH (mutant)<br />
-
[[3ah3]] – TtIDH – ''Thermus thermophilus''<br />
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**[[3ah3]] – TtIDH – ''Thermus thermophilus''<br />
-
[[3us8]] – IDH – ''Sinorhizobium meliloti''<br />
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**[[3us8]] – IDH – ''Sinorhizobium meliloti''<br />
-
[[4aoy]] – CtIDH – ''Clostridium thermocellum''
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**[[4aoy]] – CtIDH – ''Clostridium thermocellum''
-
===IDH+citrate===
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*IDH+citrate
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[[2qfw]] – yIDH+isocitrate <br />
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**[[2qfw]] – yIDH+isocitrate <br />
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[[3blv]] – yIDH+citrate<br />
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**[[3blv]] – yIDH+citrate<br />
-
[[2uxr]] – DpIDH+isocitric acid<br />
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**[[2uxr]] – DpIDH+isocitric acid<br />
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[[1itw]] – AvIDH+isocitrate+Mn – ''Azotobacter vinelandii''<br />
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**[[1itw]] – AvIDH+isocitrate+Mn – ''Azotobacter vinelandii''<br />
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[[1lwd]] – IDH+isocitrate+Mn - pig<br />
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**[[1lwd]] – IDH+isocitrate+Mn - pig<br />
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[[1pb1]], [[1p8f]] – EcIDH+isocitrate <br />
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**[[1pb1]], [[1p8f]] – EcIDH+isocitrate <br />
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[[1cw7]], [[5icd]], [[8icd]] - EcIDH +isocitrate+Mg<br />
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**[[1cw7]], [[5icd]], [[8icd]] - EcIDH +isocitrate+Mg<br />
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[[1cw1]] - EcIDH (mutant)+isocitrate+Mn<br />
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**[[1cw1]] - EcIDH (mutant)+isocitrate+Mn<br />
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[[1gro]], [[1grp]] - EcIDH (mutant)+isocitrate+Mg<br />
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**[[1gro]], [[1grp]] - EcIDH (mutant)+isocitrate+Mg<br />
-
[[1hqs]] – IDH+citrate – ''Bacillus subtilis''
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**[[1hqs]] – IDH+citrate – ''Bacillus subtilis''
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===IDH+NADP===
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*IDH+NADP
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[[1t09]] – hIDH+NADP - human<br />
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**[[1t09]] – hIDH+NADP - human<br />
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[[3mar]] – hIDH (mutant) + NADP<br />
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**[[3mar]] – hIDH (mutant) + NADP<br />
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[[2qfv]] – yIDH+NADP <br />
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**[[2qfv]] – yIDH+NADP <br />
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[[2e5m]] – StIDH+NADP <br />
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**[[2e5m]] – StIDH+NADP <br />
-
[[2cmj]] – mIDH+NADP – mouse<br />
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**[[2cmj]] – mIDH+NADP – mouse<br />
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[[1tyo]] - ApIDH+NADP<br />
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**[[1tyo]] - ApIDH+NADP<br />
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[[1j1w]] – AvIDH+NADP – ''Azotobacter vinelandii''<br />
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**[[1j1w]] – AvIDH+NADP – ''Azotobacter vinelandii''<br />
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[[9icd]] - EcIDH +NADP<br />
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**[[9icd]] - EcIDH +NADP<br />
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[[1iso]] - EcIDH (mutant)+NAD<br />
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**[[1iso]] - EcIDH (mutant)+NAD<br />
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[[3mbc]] - IDH (mutant)+NADP – ''Corynebacterium glutamicum''<br />
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**[[3mbc]] - IDH (mutant)+NADP – ''Corynebacterium glutamicum''<br />
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[[4hcx]] – IDH + NADP + Mn – ''mycobacterium tuberculosis''<br />
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**[[4hcx]] – IDH + NADP + Mn – ''mycobacterium tuberculosis''<br />
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===IDH+α-ketoglutarate===
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*IDH+α-ketoglutarate
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[[2qfy]] - yIDH+α-ketoglutarate<br />
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**[[2qfy]] - yIDH+α-ketoglutarate<br />
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[[1cw4]] – EcIDH (mutant)+α-ketoglutarate<br />
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**[[1cw4]] – EcIDH (mutant)+α-ketoglutarate<br />
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[[1ika]] - EcIDH + α-ketoglutarate+Ca<br />
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**[[1ika]] - EcIDH + α-ketoglutarate+Ca<br />
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[[3inm]], [[4l03]], [[4l04]], [[4l06]] – hIDH (mutant)+NADPH+α-ketoglutarate+Ca – human<br />
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**[[3inm]], [[4l03]], [[4l04]], [[4l06]] – hIDH (mutant)+NADPH+α-ketoglutarate+Ca – human<br />
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[[4kzo]] - hIDH +NADPH+α-ketoglutarate+Ca<br />
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**[[4kzo]] - hIDH +NADPH+α-ketoglutarate+Ca<br />
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[[2qfx]] - yIDH+NADPH+α-ketoglutarate+Ca<br />
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**[[2qfx]] - yIDH+NADPH+α-ketoglutarate+Ca<br />
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[[4ajc]] - EcIDH (mutant) +α-ketoglutarate+A2P+Ca<br />
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**[[4ajc]] - EcIDH (mutant) +α-ketoglutarate+A2P+Ca<br />
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[[4ajr]] - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg<br />
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**[[4ajr]] - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg<br />
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[[1bl5]] - EcIDH +α-ketoglutarate+NADP+Mg<br />
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**[[1bl5]] - EcIDH +α-ketoglutarate+NADP+Mg<br />
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===IDH binary complex===
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*IDH binary complex
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[[3asj]] – TtIDH + inhbibitor
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**[[3asj]] – TtIDH + inhbibitor
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===IDH ternary complexes===
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*IDH ternary complexes
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+
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[[3map]] - hIDH+NADP+isocitrate<br />
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[[3mas]] – hIDH (mutant) +NADP+isocitrate<br />
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[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
+
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[[4i3k]], [[4i3l]], [[4ja8]] - hIDH (mutant) +NADP + inhibitor<br />
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[[3blw]] – yIDH+citrate+AMP<br />
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[[2cmv]] - mIDH+NADP+citrate<br />
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[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
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[[2d1c]] – TtIDH+NADP+citrate <br />
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[[1xkd]] – ApIDH+NADP+citrate <br />
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[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
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[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
+
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[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
+
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[[1ai2]], [[4aj3]], [[4aja]] - EcIDH +isocitrate+NADP+Ca<br />
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[[1ide]], [[4ajb]] - EcIDH (mutant)+isocitrate+Mg+NADP<br />
+
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[[4ajs]] - EcIDH (mutant)+isocitrate+Mg+ A2P + NMN<br />
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[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
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[[4aov]] - DpIDH + isocitrate+NADP+Mg
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 +
**[[3map]] - hIDH+NADP+isocitrate<br />
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**[[3mas]] – hIDH (mutant) +NADP+isocitrate<br />
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**[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
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**[[4i3k]], [[4i3l]], [[4ja8]] - hIDH (mutant) +NADP + inhibitor<br />
 +
**[[3blw]] – yIDH+citrate+AMP<br />
 +
**[[2cmv]] - mIDH+NADP+citrate<br />
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**[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
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**[[2d1c]] – TtIDH+NADP+citrate <br />
 +
**[[1xkd]] – ApIDH+NADP+citrate <br />
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**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
 +
**[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
 +
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
 +
**[[1ai2]], [[4aj3]], [[4aja]] - EcIDH +isocitrate+NADP+Ca<br />
 +
**[[1ide]], [[4ajb]] - EcIDH (mutant)+isocitrate+Mg+NADP<br />
 +
**[[4ajs]] - EcIDH (mutant)+isocitrate+Mg+ A2P + NMN<br />
 +
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
 +
**[[4aov]] - DpIDH + isocitrate+NADP+Mg
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}}
=='''References'''==
=='''References'''==

Revision as of 07:58, 30 November 2014

Isocitrate dehydrogenase dimer complex with isocitrate, glycerol and Mg+2 ion (green) (PDB code 2uxr)

Drag the structure with the mouse to rotate

3D Structures of Isocitrate dehydrogenase

Updated on 30-November-2014

References

  1. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  2. ↑ Fedoy AE, Yang N, Martinez A, Leiros HK, Steen IH. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. J Mol Biol. 2007 Sep 7;372(1):130-49. Epub 2007 Jun 19. PMID:17632124 doi:10.1016/j.jmb.2007.06.040
  3. ↑ http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase#cite_note-nfr154197.2F32-6
  4. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  5. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  6. ↑ http://en.wikipedia.org/wiki/File:IDHcatalyticmechanism.jpg
  7. ↑ Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Lowenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010 Dec 14;18(6):553-67. Epub 2010 Dec 9. PMID:21130701 doi:10.1016/j.ccr.2010.11.015
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