RNA polymerase

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{{STRUCTURE_3m3y| PDB=3m3y | SIZE=400| SCENE=RNA_polymerase/Cv/1 |right|CAPTION=Yeast RNA polymerase II elongation complex C complexed with DNA and RNA and Zn+2 (grey) and Mg+2 (green) ions [[3m3y]]. Subunit B1 (grey), B2 (green), B3 (pink), B9 (wheat), B11 (rust), ABC1 (magenta), ABC2 (cyan), ABC3 (red), ABC4 (aqua), ABC5 (blue). }}
{{STRUCTURE_3m3y| PDB=3m3y | SIZE=400| SCENE=RNA_polymerase/Cv/1 |right|CAPTION=Yeast RNA polymerase II elongation complex C complexed with DNA and RNA and Zn+2 (grey) and Mg+2 (green) ions [[3m3y]]. Subunit B1 (grey), B2 (green), B3 (pink), B9 (wheat), B11 (rust), ABC1 (magenta), ABC2 (cyan), ABC3 (red), ABC4 (aqua), ABC5 (blue). }}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===DNA-dependent RNAP===
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*DNA-dependent RNA polymerase
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+
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[[2y0s]] – SsRNAP – ''Sulfolobus shibata''<br />
+
-
[[4b1p]] – SsRNAP + DNA<br />
+
-
[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br />
+
-
[[3p8b]] – PfRNAP subunit ε’’ + transcription antitermination protein – ''Pyrococcus furiosus''<br />
+
-
[[3qqc]] - PfRNAP subunits β,ε’’ + transcription antitermination protein<br />
+
-
[[1ryq]] - PfRNAP subunit ε’’<br />
+
-
[[3lpe]] - MjRNAP subunit ε’’ + transcription antitermination protein – ''Methanocaldococcus jannaschii''<br />
+
-
[[1go3]] – MjRNAP subunit RPB4, RPB7<br />
+
-
[[3aoh]], [[3aoi]] - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – ''Thermus thermophilus''<br />
+
-
[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]] - TtRNAP subunits α,β,β’,ω + DNA +RNA<br />
+
-
[[1iw7]], [[1smy]] - TtRNAP subunits α,β,β’,ω<br />
+
-
[[1zyr]], [[2a68]], [[2a69]], [[2a6e]], [[2a6h]] - TtRNAP subunits α,β,β’,ω + antibiotic<br />
+
-
[[2ppb]] - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog<br />
+
-
[[2be5]] - TtRNAP subunits α,β,β’,ω + σ factor + inhibitor<br />
+
-
[[2cw0]] - TtRNAP subunits α,β,β’,ω + σ factor<br />
+
-
[[4g7h]], [[4g7o]], [[4g7z]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA<br />
+
-
[[3dxj]], [[3eql]] - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
+
-
[[1doq]] - TtRNAP subunit α<br />
+
-
[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
+
-
[[3lti]] – EcRNAP subunit β fragment – ''Escherichia coli''<br />
+
-
[[4iqz]] - EcRNAP subunit β’ <br />
+
-
[[2lmc]] - EcRNAP subunit β + RNAP inhibitor <br />
+
-
[[3mmp]] - EcRNAP subunit β + EF-TU<br />
+
-
[[3t72]] - EcRNAP subunit β + Pho box DNA + PhoB<br />
+
-
[[3k4g]], [[1coo]] - EcRNAP subunit α<br />
+
-
[[1lb2]], [[3n4m]] - EcRNAP subunit α + DNA + CAP<br />
+
-
[[1xs9]] - EcRNAP subunit α + DNA + MARA<br />
+
-
[[3n97]] - EcRNAP subunit α C terminal + DNA + σ factor<br />
+
-
[[1bdf]] - EcRNAP subunit α (mutant)<br />
+
-
[[3lu0]] - EcRNAP subunits α,β,β’,ω – Electron diffraction<br />
+
-
[[4igc]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits α,β,β’,ω + RNA<br />
+
-
[[4kn4]], [[4kn7]] - EcRNAP subunits α,β,β’,ω + RNA + antibiotic<br />
+
-
[[4ljz]], [[4lk1]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor <br />
+
-
[[4lk0]], [[4llg]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + RNAP inhibitor<br />
+
-
[[3iyd]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA<br />
+
-
[[2l0i]] – yRNAP C-terminal + RTT103 – yeast – NMR<br />
+
-
[[1a1d]] – yRNAP subunit RPB8 – NMR<br />
+
-
[[4a3g]], [[4a93]], [[4a3b]], [[4a3c]], [[4a3d]], [[4a3e]], [[4a3f]], [[4a3j]], [[4a3k]], [[4a3l]], [[4a3m]] – yRNAP II + RNA + DNA<br />
+
-
[[4bxx]], [[4bxz]], [[4by1]], [[4by7]] – yRNAP II + RNA + DNA + transcription factor Bye1<br />
+
-
[[4c2m]], [[4c3h]], [[4c3i]], [[4c3j]] – yRNAP<br />
+
-
[[4a3i]] – yRNAP II + DNA<br />
+
-
[[2krc]] - BsRNAP subunit δ N-terminal – ''Bacillus subtilis'' – NMR<br />
+
-
[[3ihq]], [[1z3e]], [[3gfk]] - BsRNAP subunit α +regulatory protein SPX<br />
+
-
[[2ly7]] - BsRNAP subunit β − NMR<br />
+
-
[[2m4k]] - BsRNAP subunit δ − NMR<br />
+
-
[[2max]] - HpRNAP subunit α − ''Helicobacter pylori'' - NMR<br />
+
-
[[1qyp]] – RNAP II C terminal – ''Thermococcus celer'' – NMR<br />
+
-
[[3ef0]], [[3ef1]] - SpRNAP II subunit α C terminal – ''Schizosaccharomyces pombe''<br />
+
-
[[3h0g]] – SpRNAP II<br />
+
-
[[3ayh]] - SpRNAP III subunit Rpc8+Rpc9<br />
+
-
[[4kbj]] – RNAP β subunit – ''Mycobacterium tuberculosis''<br />
+
-
[[4noi]] – RNAP α subunit – ''Campylobacter jejuni''<br />
+
-
===Eukaryotic DNA-dependent RNAP===
+
**[[2y0s]] – SsRNAP – ''Sulfolobus shibata''<br />
 +
**[[4b1p]] – SsRNAP + DNA<br />
 +
**[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br />
 +
**[[3p8b]] – PfRNAP subunit ε’’ + transcription antitermination protein – ''Pyrococcus furiosus''<br />
 +
**[[3qqc]] - PfRNAP subunits β,ε’’ + transcription antitermination protein<br />
 +
**[[1ryq]] - PfRNAP subunit ε’’<br />
 +
**[[3lpe]] - MjRNAP subunit ε’’ + transcription antitermination protein – ''Methanocaldococcus jannaschii''<br />
 +
**[[1go3]] – MjRNAP subunit RPB4, RPB7<br />
 +
**[[3aoh]], [[3aoi]] - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – ''Thermus thermophilus''<br />
 +
**[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]] - TtRNAP subunits α,β,β’,ω + DNA +RNA<br />
 +
**[[1iw7]], [[1smy]] - TtRNAP subunits α,β,β’,ω<br />
 +
**[[1zyr]], [[2a68]], [[2a69]], [[2a6e]], [[2a6h]] - TtRNAP subunits α,β,β’,ω + antibiotic<br />
 +
**[[2ppb]] - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog<br />
 +
**[[2be5]] - TtRNAP subunits α,β,β’,ω + σ factor + inhibitor<br />
 +
**[[2cw0]] - TtRNAP subunits α,β,β’,ω + σ factor<br />
 +
**[[4g7h]], [[4g7o]], [[4g7z]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA<br />
 +
**[[3dxj]], [[3eql]] - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
 +
**[[1doq]] - TtRNAP subunit α<br />
 +
**[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
 +
**[[3lti]] – EcRNAP subunit β fragment – ''Escherichia coli''<br />
 +
**[[4iqz]] - EcRNAP subunit β’ <br />
 +
**[[2lmc]] - EcRNAP subunit β + RNAP inhibitor <br />
 +
**[[3mmp]] - EcRNAP subunit β + EF-TU<br />
 +
**[[3t72]] - EcRNAP subunit β + Pho box DNA + PhoB<br />
 +
**[[3k4g]], [[1coo]] - EcRNAP subunit α<br />
 +
**[[1lb2]], [[3n4m]] - EcRNAP subunit α + DNA + CAP<br />
 +
**[[1xs9]] - EcRNAP subunit α + DNA + MARA<br />
 +
**[[3n97]] - EcRNAP subunit α C terminal + DNA + σ factor<br />
 +
**[[1bdf]] - EcRNAP subunit α (mutant)<br />
 +
**[[3lu0]] - EcRNAP subunits α,β,β’,ω – Electron diffraction<br />
 +
**[[4igc]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits α,β,β’,ω + RNA<br />
 +
**[[4kn4]], [[4kn7]] - EcRNAP subunits α,β,β’,ω + RNA + antibiotic<br />
 +
**[[4ljz]], [[4lk1]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor <br />
 +
**[[4lk0]], [[4llg]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + RNAP inhibitor<br />
 +
**[[3iyd]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA<br />
 +
**[[2l0i]] – yRNAP C-terminal + RTT103 – yeast – NMR<br />
 +
**[[1a1d]] – yRNAP subunit RPB8 – NMR<br />
 +
**[[4a3g]], [[4a93]], [[4a3b]], [[4a3c]], [[4a3d]], [[4a3e]], [[4a3f]], [[4a3j]], [[4a3k]], [[4a3l]], [[4a3m]] – yRNAP II + RNA + DNA<br />
 +
**[[4bxx]], [[4bxz]], [[4by1]], [[4by7]] – yRNAP II + RNA + DNA + transcription factor Bye1<br />
 +
**[[4c2m]], [[4c3h]], [[4c3i]], [[4c3j]] – yRNAP<br />
 +
**[[4a3i]] – yRNAP II + DNA<br />
 +
**[[2krc]] - BsRNAP subunit δ N-terminal – ''Bacillus subtilis'' – NMR<br />
 +
**[[3ihq]], [[1z3e]], [[3gfk]] - BsRNAP subunit α +regulatory protein SPX<br />
 +
**[[2ly7]] - BsRNAP subunit β − NMR<br />
 +
**[[2m4k]] - BsRNAP subunit δ − NMR<br />
 +
**[[2max]] - HpRNAP subunit α − ''Helicobacter pylori'' - NMR<br />
 +
**[[1qyp]] – RNAP II C terminal – ''Thermococcus celer'' – NMR<br />
 +
**[[3ef0]], [[3ef1]] - SpRNAP II subunit α C terminal – ''Schizosaccharomyces pombe''<br />
 +
**[[3h0g]] – SpRNAP II<br />
 +
**[[3ayh]] - SpRNAP III subunit Rpc8+Rpc9<br />
 +
**[[4kbj]] – RNAP β subunit – ''Mycobacterium tuberculosis''<br />
 +
**[[4noi]] – RNAP α subunit – ''Campylobacter jejuni''<br />
-
[[3o2q]], [[3o2s]] – hRNAP II subunit α C-terminal + symplekin – human<br />
+
*Eukaryotic DNA-dependent RNA polymerase
-
[[1qkl]] - hRNAP II subunit RPB6<br />
+
-
[[3j0k]] – hRNAP II + TFIIF – Cryo EM<br />
+
-
[[2c35]] - hRNAP II subunits RPB4 RPB7 (mutant) – NMR<br />
+
-
[[2f3i]] - hRNAP II subunits RPB8 RPB17 RPABC3 – NMR<br />
+
-
[[2ghq]], [[2ght]] - hRNAP II subunits RPB1 + hRNAP II C terminal<br />
+
-
[[2q5e]], [[3l0b]], [[3l0c]] - hRNAP II C terminal<br />
+
-
[[2lto]] - hRNAP II subunit RPB1 + Tudor domain containing protein 3<br />
+
-
[[3pgl]] - hRNAP II C terminal + inhibitor<br />
+
-
[[2xub]], [[2xv4]] - hRNAP III subunits RPC3<br />
+
-
[[2dk8]] – RNAP III RPC34 domain - mouse – NMR<br />
+
-
[[2dk5]] – hRNAP III winged helix domain (mutant) – NMR<br />
+
-
[[2yu3]] - hRNAP III winged helix domain<br />
+
-
[[3spa]] - hRNAP + polypeptide<br />
+
-
[[4boc]] – hRNAP + DNA<br />
+
-
[[4lzd]] – hRNAP μ<br />
+
-
[[4lzg]], [[4m04]], [[4m0a]] – hRNAP μ + DNA<br />
+
-
[[3nff]], [[3nfg]], [[3nfh]], [[3nfi]] – RNAP I fragments (mutant) – ''Candida glabrata''<br />
+
-
[[2rf4]] - yRNAP I subunit RPA4<br />
+
-
[[1i6h]] - yRNAP II + DNA<br />
+
-
[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]] – yRNAP II<br />
+
-
[[3j1n]] – yRNAP II – Cryo EM<br />
+
-
[[1y14]] - yRNAP II subunits RPB4 RPB7<br />
+
-
[[1pqv]], [[1y1v]], [[4bbr]], [[4bbs]] - yRNAP II + TFIIS<br />
+
-
[[1y1y]] - yRNAP II + TFIIS + DNA +RNA<br />
+
-
[[2vum]] - yRNAP II + inhibitor + DNA + RNA<br />
+
-
[[3cqz]], [[1k83]] - yRNAP II + inhibitor<br />
+
-
[[1r5u]], [[3k7a]], [[3k1f]] - yRNAP II + TFIIB<br />
+
-
[[1r9s]], [[2ja5]], [[2ja6]], [[2ja7]], [[2ja8]], [[2nvq]], [[2nvt]], [[2nvx]], [[2nvy]], [[2nvz]], [[3gtg]], [[3gtj]], [[3gtk]], [[3gtl]], [[3gtm]], [[3gto]], [[3gtp]], [[3gtq]], [[3hou]], [[3hov]], [[3how]], [[3hox]], [[3hoy]], [[3hoz]], [[3po2]], [[3po3]], [[3m3y]], [[3m4o]], [[3rzd]], [[3rzo]], [[3s14]], [[3s15]], [[3s16]], [[3s17]], [[3s1m]], [[3s1n]], [[3s1q]], [[3s1r]], [[3s2d]], [[3s2h]] - yRNAP II + RNA + DNA<br />
+
-
[[1y1w]], [[1y77]], [[2r7z]], [[2r92]], [[2r93]], [[3h3v]] - yRNAP II + RNA<br />
+
-
[[1twa]], [[1twc]], [[1twf]], [[1twg]], [[1twh]] - yRNAP II + nucleotide<br />
+
-
[[2b63]] - yRNAP II + nucleotide + RNA<br />
+
-
[[2e2i]], [[2e2j]] - yRNAP II + nucleotide + DNA<br />
+
-
[[2yu9]], [[3i4m]], [[3i4n]] - yRNAP II + nucleotide + DNA + RNA<br />
+
-
[[2ckz]] - yRNAP III<br />
+
-
[[1ef4]] – MtRNAP subunit RPB10 – ''Methanothermobacter thermautotrophicus''<br />
+
-
[[1eik]] - MtRNAP subunit RPB5 – NMR<br />
+
-
===Prokaryotic DNA-dependent RNAP===
+
**[[3o2q]], [[3o2s]] – hRNAP II subunit α C-terminal + symplekin – human<br />
 +
**[[1qkl]] - hRNAP II subunit RPB6<br />
 +
**[[3j0k]] – hRNAP II + TFIIF – Cryo EM<br />
 +
**[[2c35]] - hRNAP II subunits RPB4 RPB7 (mutant) – NMR<br />
 +
**[[2f3i]] - hRNAP II subunits RPB8 RPB17 RPABC3 – NMR<br />
 +
**[[2ghq]], [[2ght]] - hRNAP II subunits RPB1 + hRNAP II C terminal<br />
 +
**[[2q5e]], [[3l0b]], [[3l0c]] - hRNAP II C terminal<br />
 +
**[[2lto]] - hRNAP II subunit RPB1 + Tudor domain containing protein 3<br />
 +
**[[3pgl]] - hRNAP II C terminal + inhibitor<br />
 +
**[[2xub]], [[2xv4]] - hRNAP III subunits RPC3<br />
 +
**[[2dk8]] – RNAP III RPC34 domain - mouse – NMR<br />
 +
**[[2dk5]] – hRNAP III winged helix domain (mutant) – NMR<br />
 +
**[[2yu3]] - hRNAP III winged helix domain<br />
 +
**[[3spa]] - hRNAP + polypeptide<br />
 +
**[[4boc]] – hRNAP + DNA<br />
 +
**[[4lzd]] – hRNAP μ<br />
 +
**[[4lzg]], [[4m04]], [[4m0a]] – hRNAP μ + DNA<br />
 +
**[[3nff]], [[3nfg]], [[3nfh]], [[3nfi]] – RNAP I fragments (mutant) – ''Candida glabrata''<br />
 +
**[[2rf4]] - yRNAP I subunit RPA4<br />
 +
**[[1i6h]] - yRNAP II + DNA<br />
 +
**[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]] – yRNAP II<br />
 +
**[[3j1n]] – yRNAP II – Cryo EM<br />
 +
**[[1y14]] - yRNAP II subunits RPB4 RPB7<br />
 +
**[[1pqv]], [[1y1v]], [[4bbr]], [[4bbs]] - yRNAP II + TFIIS<br />
 +
**[[1y1y]] - yRNAP II + TFIIS + DNA +RNA<br />
 +
**[[2vum]] - yRNAP II + inhibitor + DNA + RNA<br />
 +
**[[1r5u]], [[3k7a]], [[3k1f]] - yRNAP II + TFIIB<br />
 +
**[[1r9s]], [[2ja5]], [[2ja6]], [[2ja7]], [[2ja8]], [[2nvq]], [[2nvt]], [[2nvx]], [[2nvy]], [[2nvz]], [[3gtg]], [[3gtj]], [[3gtk]], [[3gtl]], [[3gtm]], [[3gto]], [[3gtp]], [[3gtq]], [[3hou]], [[3hov]], [[3how]], [[3hox]], [[3hoy]], [[3hoz]], [[3po2]], [[3po3]], [[3m3y]], [[3m4o]], [[3rzd]], [[3rzo]], [[3s14]], [[3s15]], [[3s16]], [[3s17]], [[3s1m]], [[3s1n]], [[3s1q]], [[3s1r]], [[3s2d]], [[3s2h]] - yRNAP II + RNA + DNA<br />
 +
**[[1y1w]], [[1y77]], [[2r7z]], [[2r92]], [[2r93]], [[3h3v]] - yRNAP II + RNA<br />
 +
**[[1twa]], [[1twc]], [[1twf]], [[1twg]], [[1twh]] - yRNAP II + nucleotide<br />
 +
**[[2b63]] - yRNAP II + nucleotide + RNA<br />
 +
**[[2e2i]], [[2e2j]] - yRNAP II + nucleotide + DNA<br />
 +
**[[2yu9]], [[3i4m]], [[3i4n]] - yRNAP II + nucleotide + DNA + RNA<br />
 +
**[[2ckz]] - yRNAP III<br />
 +
**[[1ef4]] – MtRNAP subunit RPB10 – ''Methanothermobacter thermautotrophicus''<br />
 +
**[[1eik]] - MtRNAP subunit RPB5 – NMR<br />
-
[[1hqm]] – TaRNAP subunits α,β,β’,ω − ''Thermus aquaticus''<br />
+
*Prokaryotic DNA-dependent RNA polymerase
-
[[2gho]] - TaRNAP subunits α,β,β’<br />
+
-
[[1i6v]], [[1ynj]], [[1ynn]] - TaRNAP subunits α,β,β’,ω + antibiotic<br />
+
-
[[1l9u]] - TaRNAP subunits α,β,β’,ω + σ factor<br />
+
-
[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br />
+
-
[[2auj]], [[2auk]] - TaRNAP subunit β’ <br />
+
-
[[1xpp]] – RNAP subunit L – ''Thermoplasma acidophilum''<br />
+
-
[[2jzb]] – RNAP subunit α + NUSA transcription elongation factor – ''Yersinia pseudotuberculosis''<br />
+
-
[[2waq]], [[2wb1]], [[4ayb]], [[2y0s]] – SsRNAP - ''Sulfolobus shibata''<br />
+
-
[[4b1o]] – SsRNAP + DNA<br />
+
-
[[3e7h]] – RNAP subunit β – ''Vibrio cholerae''<br />
+
-
===RNA-dependent RNAP===
+
**[[1hqm]] – TaRNAP subunits α,β,β’,ω − ''Thermus aquaticus''<br />
 +
**[[2gho]] - TaRNAP subunits α,β,β’<br />
 +
**[[1i6v]], [[1ynj]], [[1ynn]] - TaRNAP subunits α,β,β’,ω + antibiotic<br />
 +
**[[1l9u]] - TaRNAP subunits α,β,β’,ω + σ factor<br />
 +
**[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br />
 +
**[[2auj]], [[2auk]] - TaRNAP subunit β’ <br />
 +
**[[1xpp]] – RNAP subunit L – ''Thermoplasma acidophilum''<br />
 +
**[[2jzb]] – RNAP subunit α + NUSA transcription elongation factor – ''Yersinia pseudotuberculosis''<br />
 +
**[[2waq]], [[2wb1]], [[4ayb]], [[2y0s]] – SsRNAP - ''Sulfolobus shibata''<br />
 +
**[[4b1o]] – SsRNAP + DNA<br />
 +
**[[3e7h]] – RNAP subunit β – ''Vibrio cholerae''<br />
-
[[3phu]], [[1khv]], [[1khw]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
+
*RNA-dependent RNA polymerase
-
[[3phw]], [[2pt2]], [[3pt2]] – HfRNAP + ubiquitin<br />
+
-
[[3phx]] – HfRNAP + ISG15<br />
+
-
[[3pse]] - HfRNAP + ISG15 (mutant)<br />
+
-
[[2xwh]], [[2xxd]], [[2xhu]], [[2xhw]], [[3i5k]], [[1c2p]], [[1csj]], [[1quv]], [[1yuy]], [[1yv2]], [[1yvx]], [[1yvz]], [[3gsz]], [[4aep]], [[4aex]] – HvRNAP NS5B domain – Hepatitis virus<br />
+
-
[[3vc8]] - HvRNAP cytoplasmic domain C terminal<br />
+
-
[[3vcb]] - HvRNAP cytoplasmic domain C terminal (mutant)<br />
+
-
[[2xym]], [[2xhv]], [[2xi2]], [[4e76]], [[4adp]] - HvRNAP NS5B domain (mutant)<br />
+
-
[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]], [[1nhu]], [[1nhv]], [[2brk]], [[2brl]], [[2gc8]], [[2giq]], [[2gir]], [[2hai]], [[2hwh]], [[2hwi]], [[2i1r]], [[2ijn]], [[2jc0]], [[2jc1]], [[2qe2]], [[2qe5]], [[2wcx]], [[2who]], [[3ciz]], [[3cj0]], [[3cj2]], [[3cj3]], [[3cj4]], [[3cj5]], [[3cso]], [[3cvk]], [[3fqk]], [[3fql]], [[3gol]], [[3h5s]], [[3h5u]], [[3q0z]], [[3qgd]], [[3qge]], [[3qgf]], [[3qgg]], [[3qgh]], [[3qgi]], [[3ska]], [[3ske]], [[3skh]], [[3uph]], [[3upi]], [[4dru]], [[3vqs]], [[3udl]], [[4eo6]], [[4eo8]], [[4eaw]], [[4gmc]], [[4ih5]], [[4ih6]], [[4ih7]], [[4iz0]], [[4jtz]], [[4jtw]], [[4jty]], [[4ju1]], [[4ju2]], [[4jjs]], [[4jju]], [[4j02]], [[4j04]], [[4j06]], [[4j08]], [[2yoj]], [[3tuq]], [[3tuv]], [[3u4o]], [[3u4r]], [[4mk7]], [[4mk8]], [[4mk9]], [[4mka]], [[4mkb]], [[4mz4]], [[4nld]] - HvRNAP NS5B domain + inhibitor<br />
+
-
[[3gyn]], [[1os5]], [[3br9]], [[3bsa]], [[3bsc]], [[3cde]], [[3co9]], [[3cwj]], [[3d28]], [[3d5m]], [[3e51]], [[3frz]], [[3igv]], [[3hvo]], [[3h2l]], [[4kai]], [[4kb7]], [[4kbi]], [[4ke5]], [[4khm]], [[4khr]] - HvRNAP NS5B domain (mutant) + inhibitor<br />
+
-
[[2wrm]], [[3mwv]], [[3mww]] – HvRNAP NS5B domain<br />
+
-
[[2xi3]] - HvRNAP NS5B domain (mutant) + nucleotide<br />
+
-
[[1gx5]], [[1gx6]] - HvRNAP NS5B domain + nucleotide<br />
+
-
[[4e78]], [[4e7a]] - HvRNAP NS5B domain (mutant) + RNA<br />
+
-
[[3ol6]], [[2jlg]], [[4k4s]], [[4k4t]], [[4k4u]], [[4k4v]], [[4k4w]] – PoRNAP (mutant) + RNA – Poliovirus<br />
+
-
[[1rdr]] - PoRNAP <br />
+
-
[[1tql]], [[2ijd]], [[2ijf]], [[4nlo]], [[4nlp]], [[4nlq]], [[4nlr]], [[4nls]], [[4nlt]], [[4nlu]], [[4nlv]], [[4nlw]], [[4nlx]], [[4nly]] - PoRNAP (mutant)<br />
+
-
[[3ol7]], [[3ol8]], [[3ol9]], [[3ola]], [[3olb]] - PoRNAP (mutant) + RNA + nucleotide<br />
+
-
[[2im1]], [[2im0]], [[2im2]], [[2im3]], [[2ily]], [[2ilz]] - PoRNAP (mutant) + nucleotide<br />
+
-
[[2xi5]], [[2xi7]] – RNAP L N-terminal – Bunyavirus<br />
+
-
[[3jsb]] – RNAP (mutant) – Lymphocytic choriomengitis virus<br />
+
-
[[2wk4]], [[2uut]], [[2uuw]] – SvRNAP (mutant) – Sapporo virus<br />
+
-
[[2ckw]] - SvRNAP residues 1135-1649<br />
+
-
[[3klv]], [[3kmq]], [[3kms]], [[3kna]], [[3nl0]] – FmRNAP (mutant) + RNA – Foot-and-mouth virus<br />
+
-
[[3nky]] - FmRNAP (mutant)<br />
+
-
[[3koa]] - FmRNAP (mutant) + RNA + nucleotide<br />
+
-
[[1wne]] – FmRNAP + RNA <br />
+
-
[[2e9r]], [[2e9t]], [[2e9z]], [[2ec0]] - FmRNAP + RNA + inhibitor<br />
+
-
[[2d7s]], [[2f8e]] – FmRNAP + VPG protein<br />
+
-
[[1hhs]], [[4a8o]], [[4b02]] – P6RNAP – Bacteriophage φ-6<br />
+
-
[[2jl9]], [[2jlf]] – P6RNAP (mutant)<br />
+
-
[[1uvi]], [[1uvl]], [[1uvm]], [[1uvn]], [[4a8f]], [[4a8k]], [[4a8m]], [[4a8q]], [[4a8s]], [[4a8w]], [[4a8y]] – P6RNAP + RNA<br />
+
-
[[2po4]] – N4RNAP polymerase domain – Bacteriophage N4<br />
+
-
[[3c2p]], [[3c3l]], [[3c46]], [[3q0a]] - N4RNAP polymerase domain + promoter DNA<br />
+
-
[[1l9k]] – DevRNAP N terminal – Dengue virus<br />
+
-
[[2j7u]], [[4c11]] - DevRNAP polymerase domain<br />
+
-
[[1oks]] – RNAP α subunit – Measles virus<br />
+
-
[[1r4g]] - RNAP α subunit – Sendai virus – NMR<br />
+
-
[[1s48]], [[1s49]], [[1s4f]] – DvRNAP residues 71-679 – Diarrhea virus<br />
+
-
[[2cjq]] - DvRNAP polymerase domain<br />
+
-
[[1sh0]], [[1sh2]], [[1sh3]] - NvRNAP C terminal – Norwalk virus<br />
+
-
[[3bsn]], [[3bso]], [[3h5x]], [[3h5y]] - NvRNAP + RNA + nucleotide<br />
+
-
[[1vyi]] - RNAP α subunit C terminal – Rabies virus<br />
+
-
[[2hcn]], [[2hcs]], [[2hfz]] – RNAP polymerase domain – West Nile virus<br />
+
-
[[2pgg]], [[2pus]] – RNAP – Bursal disease virus<br />
+
-
[[2r7o]], [[2r7q]] – SrRNAP – Simian rotavirus<br />
+
-
[[4f5x]] – SrRNAP + Vp2 + Vp6<br />
+
-
[[4au6]] - RNAP – bovine rotavirus – Cryo-EM<br />
+
-
[[2yi8]], [[2yi9]], [[2yia]], [[2yib]] – IpnvRNAP – Infectious pancreatic necrosis virus<br />
+
-
[[3zed]] – IpnvRNAP + capsid protein Vp3<br />
+
-
[[3n6l]] – EvRNAP – Human enterovirus<br />
+
-
[[3n6m]], [[3n6n]] – EvRNAP + nucleotide<br />
+
-
[[3nah]], [[3nai]], [[3qid]], [[3uqs]] – MnvRNAP – Murine norovirus<br />
+
-
[[3sfg]] – MnvRNAP + thio-uridine<br />
+
-
[[3sfu]] – MnvRNAP + ribavirine<br />
+
-
[[3upf]], [[3ur0]] – MnvRNAP + inhibitor<br />
+
-
[[4lq3]], [[4lq9]] – RNAP + inhibitor – human norovirus <br />
+
-
[[2r7r]], [[2r7s]], [[2r7t]], [[2r7u]], [[2r7v]], [[2r7w]], [[2r7x]] – SrRNAP + RNA<br />
+
-
[[3cdu]] – CvRNAP + POP – Coxsakievirus<br />
+
-
[[3ddk]] - CvRNAP<br />
+
-
[[3cdw]] - CvRNAP + POP + VPG<br />
+
-
[[3eva]], [[3evb]], [[3evc]], [[3evd]], [[3eve]], [[3evf]], [[3evg]] – RNAP N terminal + nucleotide – Yellow fever virus<br />
+
-
[[2j7n]], [[2j7o]] – RNAP residues 381-1402 – ''Neurospora crassa''<br />
+
-
[[4hxd]] – RNAP L + polyubiquitin-C – Dugbe virus<br />
+
-
[[4k50]] – RNAP + RNA – Human rhinovirus<br />
+
-
[[4gzk]], [[4ieg]] – RNAP – cystovirus 12<br />
+
-
[[4i1t]] – RNAP L – Pichinde virus <br />
+
-
[[4miw]] – RNAP L N terminal – Lassa virus <br />
+
-
[[4miw]] – RNAP L N terminal – Encephalitis virus <br />
+
-
===Influenza virus RNAP (Polymerase acidic protein - PAP)===
+
**[[3phu]], [[1khv]], [[1khw]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
 +
**[[3phw]], [[2pt2]], [[3pt2]] – HfRNAP + ubiquitin<br />
 +
**[[3phx]] – HfRNAP + ISG15<br />
 +
**[[3pse]] - HfRNAP + ISG15 (mutant)<br />
 +
**[[2xwh]], [[2xxd]], [[2xhu]], [[2xhw]], [[3i5k]], [[1c2p]], [[1csj]], [[1quv]], [[1yuy]], [[1yv2]], [[1yvx]], [[1yvz]], [[3gsz]], [[4aep]], [[4aex]] – HvRNAP NS5B domain – Hepatitis virus<br />
 +
**[[3vc8]] - HvRNAP cytoplasmic domain C terminal<br />
 +
**[[3vcb]] - HvRNAP cytoplasmic domain C terminal (mutant)<br />
 +
**[[2xym]], [[2xhv]], [[2xi2]], [[4e76]], [[4adp]] - HvRNAP NS5B domain (mutant)<br />
 +
**[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]], [[1nhu]], [[1nhv]], [[2brk]], [[2brl]], [[2gc8]], [[2giq]], [[2gir]], [[2hai]], [[2hwh]], [[2hwi]], [[2i1r]], [[2ijn]], [[2jc0]], [[2jc1]], [[2qe2]], [[2qe5]], [[2wcx]], [[2who]], [[3ciz]], [[3cj0]], [[3cj2]], [[3cj3]], [[3cj4]], [[3cj5]], [[3cso]], [[3cvk]], [[3fqk]], [[3fql]], [[3gol]], [[3h5s]], [[3h5u]], [[3q0z]], [[3qgd]], [[3qge]], [[3qgf]], [[3qgg]], [[3qgh]], [[3qgi]], [[3ska]], [[3ske]], [[3skh]], [[3uph]], [[3upi]], [[4dru]], [[3vqs]], [[3udl]], [[4eo6]], [[4eo8]], [[4eaw]], [[4gmc]], [[4ih5]], [[4ih6]], [[4ih7]], [[4iz0]], [[4jtz]], [[4jtw]], [[4jty]], [[4ju1]], [[4ju2]], [[4jjs]], [[4jju]], [[4j02]], [[4j04]], [[4j06]], [[4j08]], [[2yoj]], [[3tuq]], [[3tuv]], [[3u4o]], [[3u4r]], [[4mk7]], [[4mk8]], [[4mk9]], [[4mka]], [[4mkb]], [[4mz4]], [[4nld]] - HvRNAP NS5B domain + inhibitor<br />
 +
**[[3gyn]], [[1os5]], [[3br9]], [[3bsa]], [[3bsc]], [[3cde]], [[3co9]], [[3cwj]], [[3d28]], [[3d5m]], [[3e51]], [[3frz]], [[3igv]], [[3hvo]], [[3h2l]], [[4kai]], [[4kb7]], [[4kbi]], [[4ke5]], [[4khm]], [[4khr]] - HvRNAP NS5B domain (mutant) + inhibitor<br />
 +
**[[2wrm]], [[3mwv]], [[3mww]] – HvRNAP NS5B domain<br />
 +
**[[2xi3]] - HvRNAP NS5B domain (mutant) + nucleotide<br />
 +
**[[1gx5]], [[1gx6]] - HvRNAP NS5B domain + nucleotide<br />
 +
**[[4e78]], [[4e7a]] - HvRNAP NS5B domain (mutant) + RNA<br />
 +
**[[3ol6]], [[2jlg]], [[4k4s]], [[4k4t]], [[4k4u]], [[4k4v]], [[4k4w]] – PoRNAP (mutant) + RNA – Poliovirus<br />
 +
**[[1rdr]] - PoRNAP <br />
 +
**[[1tql]], [[2ijd]], [[2ijf]], [[4nlo]], [[4nlp]], [[4nlq]], [[4nlr]], [[4nls]], [[4nlt]], [[4nlu]], [[4nlv]], [[4nlw]], [[4nlx]], [[4nly]] - PoRNAP (mutant)<br />
 +
**[[3ol7]], [[3ol8]], [[3ol9]], [[3ola]], [[3olb]] - PoRNAP (mutant) + RNA + nucleotide<br />
 +
**[[2im1]], [[2im0]], [[2im2]], [[2im3]], [[2ily]], [[2ilz]] - PoRNAP (mutant) + nucleotide<br />
 +
**[[2xi5]], [[2xi7]] – RNAP L N-terminal – Bunyavirus<br />
 +
**[[3jsb]] – RNAP (mutant) – Lymphocytic choriomengitis virus<br />
 +
**[[2wk4]], [[2uut]], [[2uuw]] – SvRNAP (mutant) – Sapporo virus<br />
 +
**[[2ckw]] - SvRNAP residues 1135-1649<br />
 +
**[[3klv]], [[3kmq]], [[3kms]], [[3kna]], [[3nl0]] – FmRNAP (mutant) + RNA – Foot-and-mouth virus<br />
 +
**[[3nky]] - FmRNAP (mutant)<br />
 +
**[[3koa]] - FmRNAP (mutant) + RNA + nucleotide<br />
 +
**[[1wne]] – FmRNAP + RNA <br />
 +
**[[2e9r]], [[2e9t]], [[2e9z]], [[2ec0]] - FmRNAP + RNA + inhibitor<br />
 +
**[[2d7s]], [[2f8e]] – FmRNAP + VPG protein<br />
 +
**[[1hhs]], [[4a8o]], [[4b02]] – P6RNAP – Bacteriophage φ-6<br />
 +
**[[2jl9]], [[2jlf]] – P6RNAP (mutant)<br />
 +
**[[1uvi]], [[1uvl]], [[1uvm]], [[1uvn]], [[4a8f]], [[4a8k]], [[4a8m]], [[4a8q]], [[4a8s]], [[4a8w]], [[4a8y]] – P6RNAP + RNA<br />
 +
**[[2po4]] – N4RNAP polymerase domain – Bacteriophage N4<br />
 +
**[[3c2p]], [[3c3l]], [[3c46]], [[3q0a]] - N4RNAP polymerase domain + promoter DNA<br />
 +
**[[1l9k]] – DevRNAP N terminal – Dengue virus<br />
 +
**[[2j7u]], [[4c11]] - DevRNAP polymerase domain<br />
 +
**[[1oks]] – RNAP α subunit – Measles virus<br />
 +
**[[1r4g]] - RNAP α subunit – Sendai virus – NMR<br />
 +
**[[1s48]], [[1s49]], [[1s4f]] – DvRNAP residues 71-679 – Diarrhea virus<br />
 +
**[[2cjq]] - DvRNAP polymerase domain<br />
 +
**[[1sh0]], [[1sh2]], [[1sh3]] - NvRNAP C terminal – Norwalk virus<br />
 +
**[[3bsn]], [[3bso]], [[3h5x]], [[3h5y]] - NvRNAP + RNA + nucleotide<br />
 +
**[[1vyi]] - RNAP α subunit C terminal – Rabies virus<br />
 +
**[[2hcn]], [[2hcs]], [[2hfz]] – RNAP polymerase domain – West Nile virus<br />
 +
**[[2pgg]], [[2pus]] – RNAP – Bursal disease virus<br />
 +
**[[2r7o]], [[2r7q]] – SrRNAP – Simian rotavirus<br />
 +
**[[4f5x]] – SrRNAP + Vp2 + Vp6<br />
 +
**[[4au6]] - RNAP – bovine rotavirus – Cryo-EM<br />
 +
**[[2yi8]], [[2yi9]], [[2yia]], [[2yib]] – IpnvRNAP – Infectious pancreatic necrosis virus<br />
 +
**[[3zed]] – IpnvRNAP + capsid protein Vp3<br />
 +
**[[3n6l]] – EvRNAP – Human enterovirus<br />
 +
**[[3n6m]], [[3n6n]] – EvRNAP + nucleotide<br />
 +
**[[3nah]], [[3nai]], [[3qid]], [[3uqs]] – MnvRNAP – Murine norovirus<br />
 +
**[[3sfg]] – MnvRNAP + thio-uridine<br />
 +
**[[3sfu]] – MnvRNAP + ribavirine<br />
 +
**[[3upf]], [[3ur0]] – MnvRNAP + inhibitor<br />
 +
**[[4lq3]], [[4lq9]] – RNAP + inhibitor – human norovirus <br />
 +
**[[2r7r]], [[2r7s]], [[2r7t]], [[2r7u]], [[2r7v]], [[2r7w]], [[2r7x]] – SrRNAP + RNA<br />
 +
**[[3cdu]] – CvRNAP + POP – Coxsakievirus<br />
 +
**[[3ddk]] - CvRNAP<br />
 +
**[[3cdw]] - CvRNAP + POP + VPG<br />
 +
**[[3eva]], [[3evb]], [[3evc]], [[3evd]], [[3eve]], [[3evf]], [[3evg]] – RNAP N terminal + nucleotide – Yellow fever virus<br />
 +
**[[2j7n]], [[2j7o]] – RNAP residues 381-1402 – ''Neurospora crassa''<br />
 +
**[[4hxd]] – RNAP L + polyubiquitin-C – Dugbe virus<br />
 +
**[[4k50]] – RNAP + RNA – Human rhinovirus<br />
 +
**[[4gzk]], [[4ieg]] – RNAP – cystovirus 12<br />
 +
**[[4i1t]] – RNAP L – Pichinde virus <br />
 +
**[[4miw]] – RNAP L N terminal – Lassa virus <br />
-
[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP subunit P2 (mutant) + Mn + nucleotide – Influenza virus<br />
+
*Influenza virus RNA polymerase (Polymerase acidic protein - PAP)
-
[[3hw6]] - IvRNAP subunit P2 (mutant) + Mn <br />
+
-
[[3cm8 - IvPAP subunit P2 + RNA-directed RNA polymerase subunit P2 peptide<br />
+
-
[[4e5e]] - IvPAP residues 1-50, 73-196 + Mn<br />
+
-
[[4e5f]], [[4e5g]], [[4e5h]], [[4e5i]], [[4e5j]], [[4e5l]] - IvPAP residues 1-50, 73-196 + Mn + inhibitor<br />
+
-
[[2znl]] - IvRNAP subunit P1 + PAP subunit P2<br />
+
-
[[2ztt]], [[3a1g]] - IvRNAP subunit P1 + PAP N terminal<br />
+
-
[[2w69]] - IvRNAP subunit PA<br />
+
-
[[4iuj]] - IvRNAP subunit P2<br />
+
-
[[2gmo]], [[3cw4]] - IvRNAP subunit P3<br />
+
-
[[2vqz]] - IvRNAP subunit P3 CAP-binding domain<br />
+
-
[[2vy6]] - IvRNAP subunit P3 627- and NLS domains<br />
+
-
[[2vy7]] - IvRNAP subunit P3 627-domain<br />
+
-
[[2vy8]] - IvRNAP subunit P3 627-domain (mutant)<br />
+
-
===DNA primase===
+
**[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP subunit P2 (mutant) + Mn + nucleotide – Influenza virus<br />
 +
**[[3hw6]] - IvRNAP subunit P2 (mutant) + Mn <br />
 +
**[[3cm8 - IvPAP subunit P2 + RNA-directed RNA polymerase subunit P2 peptide<br />
 +
**[[4e5e]] - IvPAP residues 1-50, 73-196 + Mn<br />
 +
**[[4e5f]], [[4e5g]], [[4e5h]], [[4e5i]], [[4e5j]], [[4e5l]] - IvPAP residues 1-50, 73-196 + Mn + inhibitor<br />
 +
**[[2znl]] - IvRNAP subunit P1 + PAP subunit P2<br />
 +
**[[2ztt]], [[3a1g]] - IvRNAP subunit P1 + PAP N terminal<br />
 +
**[[2w69]] - IvRNAP subunit PA<br />
 +
**[[4iuj]] - IvRNAP subunit P2<br />
 +
**[[2gmo]], [[3cw4]] - IvRNAP subunit P3<br />
 +
**[[2vqz]] - IvRNAP subunit P3 CAP-binding domain<br />
 +
**[[2vy6]] - IvRNAP subunit P3 627- and NLS domains<br />
 +
**[[2vy7]] - IvRNAP subunit P3 627-domain<br />
 +
**[[2vy8]] - IvRNAP subunit P3 627-domain (mutant)<br />
-
[[4lik]] - hDNAP small subunit<br />
+
*DNA primase
-
[[4lil]] - hDNAP small subunit + UTP<br />
+
-
[[3q36]] – hDNAP large subunit<br />
+
-
[[4bpu]] - hDNAP small (mutant) + large subunit<br />
+
-
[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br />
+
-
[[4bpx]] - hDNAP small (mutant) + DNA polymerase α subunit<br />
+
-
[[4ehs]] – HpDNAP C terminal<br />
+
-
[[4lim]] - yDNAP small subunit<br />
+
-
[[3lgb]] - yDNAP large subunit<br />
+
-
[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br />
+
-
[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br />
+
-
[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br />
+
-
[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br />
+
-
[[1v34]] - PhDNAP small subunit + nucleotide<br />
+
-
[[1g71]] - PfDNAP small subunit<br />
+
-
[[1q57]] – T7DNAP/helicase (mutant) – Enterobacteria phage T7<br />
+
-
[[1nui]] – T7DNAP/helicase primase fragment (mutant)<br />
+
-
[[1cr0]] - T7DNAP/helicase helicase domain<br />
+
-
[[1cr1]], [[1cr2]], [[1cr4]] - T7DNAP/helicase helicase domain + nucleotide<br />
+
-
[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br />
+
-
[[2lzn]] – SaDNAP C terminal – NMR<br />
+
-
[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide
+
-
===Bacterial primase===
+
**[[4lik]] - hDNAP small subunit<br />
 +
**[[4lil]] - hDNAP small subunit + UTP<br />
 +
**[[3q36]] – hDNAP large subunit<br />
 +
**[[4bpu]] - hDNAP small (mutant) + large subunit<br />
 +
**[[4bpw]] - hDNAP small (mutant) + large subunit + UTP<br />
 +
**[[4bpx]] - hDNAP small (mutant) + DNA polymerase α subunit<br />
 +
**[[4ehs]] – HpDNAP C terminal<br />
 +
**[[4lim]] - yDNAP small subunit<br />
 +
**[[3lgb]] - yDNAP large subunit<br />
 +
**[[3m1m]] – DNAP RNA polymerase domain – ''Sulfolobus islandicus''<br />
 +
**[[1zt2]], [[2pa8]], [[2pmz]], [[3hkz]] - DNAP small + large subunit – ''Sulfolobus solfataricus''<br />
 +
**[[2au3]] – DNAP zinc-binding and RNA polymerase domains – ''Aquifex aeolicus''<br />
 +
**[[1v33]] - PhDNAP small subunit – ''Pyrocuccus horikoshii''<br />
 +
**[[1v34]] - PhDNAP small subunit + nucleotide<br />
 +
**[[1g71]] - PfDNAP small subunit<br />
 +
**[[1q57]] – T7DNAP/helicase (mutant) – Enterobacteria phage T7<br />
 +
**[[1nui]] – T7DNAP/helicase primase fragment (mutant)<br />
 +
**[[1cr0]] - T7DNAP/helicase helicase domain<br />
 +
**[[1cr1]], [[1cr2]], [[1cr4]] - T7DNAP/helicase helicase domain + nucleotide<br />
 +
**[[4e2k]] – SaDNAP – ''Staphylococcus aureus''<br />
 +
**[[2lzn]] – SaDNAP C terminal – NMR<br />
 +
**[[4edg]], [[4edk]], [[4edr]], [[4edt]], [[4edv]], [[4ee1]] – SaDNAP + nucleotide
-
[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br />
+
*Bacterial primase
-
[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br />
+
-
[[1d0q]] - GsDNAP zinc-binding domain<br />
+
-
[[1z8s]] - GsdnaG dnaB binding domain - NMR<br />
+
-
[[2haj]] - EcdnaG catalytic domain - NMR<br />
+
-
[[3b39]] – EcdnaG catalytic domain + DNA<br />
+
-
[[1t3w]] – EcdnaG C-terminal<br />
+
-
[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br />
+
-
===RNA polymerase from Bacteriophage T7===
+
**[[2r6a]], [[2r6c]] - GsdnaG helicase binding domain + helicase – ''Geobacillus stearothermophilus''<br />
 +
**[[4m4w]] - GsdnaG helicase binding domain + helicase + DnaI<br />
 +
**[[1d0q]] - GsDNAP zinc-binding domain<br />
 +
**[[1z8s]] - GsdnaG dnaB binding domain - NMR<br />
 +
**[[2haj]] - EcdnaG catalytic domain - NMR<br />
 +
**[[3b39]] – EcdnaG catalytic domain + DNA<br />
 +
**[[1t3w]] – EcdnaG C-terminal<br />
 +
**[[1eqn]], [[1dd9]], [[1dde]] – EcdnaG catalytic core<br />
-
[[4rnp]] – T7RNAP<br />
+
*RNA polymerase from Bacteriophage T7
-
[[1aro]] – T7RNAP + T7 lysozyme<br />
+
-
[[1cez]], [[1h38]], [[1qln]], [[2pi4]], [[2pi5]] - T7RNAP + DNA<br />
+
-
[[1msw]], [[1s0v]], [[1s76]], [[1s77]], [[3e2e]], [[3e3j]] - T7RNAP + DNA + RNA<br />
+
-
===Poly(A) RNA polymerase===
+
**[[4rnp]] – T7RNAP<br />
 +
**[[1aro]] – T7RNAP + T7 lysozyme<br />
 +
**[[1cez]], [[1h38]], [[1qln]], [[2pi4]], [[2pi5]] - T7RNAP + DNA<br />
 +
**[[1msw]], [[1s0v]], [[1s76]], [[1s77]], [[3e2e]], [[3e3j]] - T7RNAP + DNA + RNA<br />
-
[[3pq1]] – hPAP (mutant)<br />
+
*Poly(A) RNA polymerase
-
[[4lt6]] – hPAP γ <br />
+
-
[[4nkt]] – SpPAP (mutant) + UMPNPP <br />
+
-
[[4nku]] – SpPAP (mutant) + RNA <br />
+
-
[[3nyb]] – yPAP + AIR2<br />
+
-
[[4e7x]], [[4e80]], [[4e8f]], [[4ep7]], [[4fh3]] – fyPAP Cid1 – fission yeast<br />
+
-
[[4fh5]], [[4fhp]], [[4fhv]], [[4fhw]], [[4fhy]] – fyPAP Cid1 + nucleotide<br />
+
-
[[4fhx]] – fyPAP Cid1 (mutant) + nucleotide
+
 +
**[[3pq1]] – hPAP (mutant)<br />
 +
**[[4lt6]] – hPAP γ <br />
 +
**[[4nkt]] – SpPAP (mutant) + UMPNPP <br />
 +
**[[4nku]] – SpPAP (mutant) + RNA <br />
 +
**[[3nyb]] – yPAP + AIR2<br />
 +
**[[4e7x]], [[4e80]], [[4e8f]], [[4ep7]], [[4fh3]] – fyPAP Cid1 – fission yeast<br />
 +
**[[4fh5]], [[4fhp]], [[4fhv]], [[4fhw]], [[4fhy]] – fyPAP Cid1 + nucleotide<br />
 +
**[[4fhx]] – fyPAP Cid1 (mutant) + nucleotide
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]
*Created with the participation of [[User:Craig T Martin|Craig T Martin]].
*Created with the participation of [[User:Craig T Martin|Craig T Martin]].

Revision as of 11:41, 9 December 2014

Template:STRUCTURE 3m3y

RNA polymerase (RNAP, DNA primase, dnaG) catalyzes the addition of nucleotides to RNA during transcription. DNA primase (DNAP) is RNAP which catalyzes the synthesis of the RNA primer which complements an ssDNA template and initiates DNA synthesis. dnaG is a bacterial primase. Polymerase acidic protein (PAP) is an Influenza virus RNA polymerase. It is implicated in endonuclease cleavage of RNA primers. (1qln; blue: nontemplate strand; cyan: template strand; red:RNA). See also Transcription and RNA Processing.
For RNA polymerase from bacteriophage T7 see

For RNA-dependent RNA polymerase from Hepatitis C virus - NS5B - see

For DNA-dependent RNA polymerase see

For the Thermus thermophilus β' subunit see

For the influenza virus RNA-dependent RNA polymerase PB2 and PA homology model and sequence alignment see

3D Structures of RNA polymerase

Updated on 09-December-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

  • DNA-dependent RNA polymerase
    • 2y0s – SsRNAP – Sulfolobus shibata
    • 4b1p – SsRNAP + DNA
    • 3q22, 3q23, 3q24, 4ff1, 4ff2, 4ff3, 4ff4 – RNAP + DNA – Enterobacteria phage N4
    • 3p8b – PfRNAP subunit ε’’ + transcription antitermination protein – Pyrococcus furiosus
    • 3qqc - PfRNAP subunits β,ε’’ + transcription antitermination protein
    • 1ryq - PfRNAP subunit ε’’
    • 3lpe - MjRNAP subunit ε’’ + transcription antitermination protein – Methanocaldococcus jannaschii
    • 1go3 – MjRNAP subunit RPB4, RPB7
    • 3aoh, 3aoi - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – Thermus thermophilus
    • 2o5i, 2o5j, 4gzy, 4gzz - TtRNAP subunits α,β,β’,ω + DNA +RNA
    • 1iw7, 1smy - TtRNAP subunits α,β,β’,ω
    • 1zyr, 2a68, 2a69, 2a6e, 2a6h - TtRNAP subunits α,β,β’,ω + antibiotic
    • 2ppb - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog
    • 2be5 - TtRNAP subunits α,β,β’,ω + σ factor + inhibitor
    • 2cw0 - TtRNAP subunits α,β,β’,ω + σ factor
    • 4g7h, 4g7o, 4g7z - TtRNAP subunits α,β,β’,ω + σ factor + DNA
    • 3dxj, 3eql - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic
    • 1doq - TtRNAP subunit α
    • 3mlq - TtRNAP subunit β + transcription-repair coupling factor
    • 3lti – EcRNAP subunit β fragment – Escherichia coli
    • 4iqz - EcRNAP subunit β’
    • 2lmc - EcRNAP subunit β + RNAP inhibitor
    • 3mmp - EcRNAP subunit β + EF-TU
    • 3t72 - EcRNAP subunit β + Pho box DNA + PhoB
    • 3k4g, 1coo - EcRNAP subunit α
    • 1lb2, 3n4m - EcRNAP subunit α + DNA + CAP
    • 1xs9 - EcRNAP subunit α + DNA + MARA
    • 3n97 - EcRNAP subunit α C terminal + DNA + σ factor
    • 1bdf - EcRNAP subunit α (mutant)
    • 3lu0 - EcRNAP subunits α,β,β’,ω – Electron diffraction
    • 4igc, 4jk1, 4jk2, 4jkr, 4kmu - EcRNAP subunits α,β,β’,ω + RNA
    • 4kn4, 4kn7 - EcRNAP subunits α,β,β’,ω + RNA + antibiotic
    • 4ljz, 4lk1 - EcRNAP subunits α,β,β’,ω + RNAP sigma factor
    • 4lk0, 4llg - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + RNAP inhibitor
    • 3iyd - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA
    • 2l0i – yRNAP C-terminal + RTT103 – yeast – NMR
    • 1a1d – yRNAP subunit RPB8 – NMR
    • 4a3g, 4a93, 4a3b, 4a3c, 4a3d, 4a3e, 4a3f, 4a3j, 4a3k, 4a3l, 4a3m – yRNAP II + RNA + DNA
    • 4bxx, 4bxz, 4by1, 4by7 – yRNAP II + RNA + DNA + transcription factor Bye1
    • 4c2m, 4c3h, 4c3i, 4c3j – yRNAP
    • 4a3i – yRNAP II + DNA
    • 2krc - BsRNAP subunit δ N-terminal – Bacillus subtilis – NMR
    • 3ihq, 1z3e, 3gfk - BsRNAP subunit α +regulatory protein SPX
    • 2ly7 - BsRNAP subunit β − NMR
    • 2m4k - BsRNAP subunit δ − NMR
    • 2max - HpRNAP subunit α − Helicobacter pylori - NMR
    • 1qyp – RNAP II C terminal – Thermococcus celer – NMR
    • 3ef0, 3ef1 - SpRNAP II subunit α C terminal – Schizosaccharomyces pombe
    • 3h0g – SpRNAP II
    • 3ayh - SpRNAP III subunit Rpc8+Rpc9
    • 4kbj – RNAP β subunit – Mycobacterium tuberculosis
    • 4noi – RNAP α subunit – Campylobacter jejuni
  • Eukaryotic DNA-dependent RNA polymerase
  • Prokaryotic DNA-dependent RNA polymerase
    • 1hqm – TaRNAP subunits α,β,β’,ω − Thermus aquaticus
    • 2gho - TaRNAP subunits α,β,β’
    • 1i6v, 1ynj, 1ynn - TaRNAP subunits α,β,β’,ω + antibiotic
    • 1l9u - TaRNAP subunits α,β,β’,ω + σ factor
    • 1l9z - TaRNAP subunits α,β,β’,ω + σ factor + DNA
    • 2auj, 2auk - TaRNAP subunit β’
    • 1xpp – RNAP subunit L – Thermoplasma acidophilum
    • 2jzb – RNAP subunit α + NUSA transcription elongation factor – Yersinia pseudotuberculosis
    • 2waq, 2wb1, 4ayb, 2y0s – SsRNAP - Sulfolobus shibata
    • 4b1o – SsRNAP + DNA
    • 3e7h – RNAP subunit β – Vibrio cholerae
  • RNA-dependent RNA polymerase
  • Influenza virus RNA polymerase (Polymerase acidic protein - PAP)
    • 3hw3, 3hw4, 3hw5 - IvRNAP subunit P2 (mutant) + Mn + nucleotide – Influenza virus
    • 3hw6 - IvRNAP subunit P2 (mutant) + Mn
    • [[3cm8 - IvPAP subunit P2 + RNA-directed RNA polymerase subunit P2 peptide
    • 4e5e - IvPAP residues 1-50, 73-196 + Mn
    • 4e5f, 4e5g, 4e5h, 4e5i, 4e5j, 4e5l - IvPAP residues 1-50, 73-196 + Mn + inhibitor
    • 2znl - IvRNAP subunit P1 + PAP subunit P2
    • 2ztt, 3a1g - IvRNAP subunit P1 + PAP N terminal
    • 2w69 - IvRNAP subunit PA
    • 4iuj - IvRNAP subunit P2
    • 2gmo, 3cw4 - IvRNAP subunit P3
    • 2vqz - IvRNAP subunit P3 CAP-binding domain
    • 2vy6 - IvRNAP subunit P3 627- and NLS domains
    • 2vy7 - IvRNAP subunit P3 627-domain
    • 2vy8 - IvRNAP subunit P3 627-domain (mutant)
  • DNA primase
    • 4lik - hDNAP small subunit
    • 4lil - hDNAP small subunit + UTP
    • 3q36 – hDNAP large subunit
    • 4bpu - hDNAP small (mutant) + large subunit
    • 4bpw - hDNAP small (mutant) + large subunit + UTP
    • 4bpx - hDNAP small (mutant) + DNA polymerase α subunit
    • 4ehs – HpDNAP C terminal
    • 4lim - yDNAP small subunit
    • 3lgb - yDNAP large subunit
    • 3m1m – DNAP RNA polymerase domain – Sulfolobus islandicus
    • 1zt2, 2pa8, 2pmz, 3hkz - DNAP small + large subunit – Sulfolobus solfataricus
    • 2au3 – DNAP zinc-binding and RNA polymerase domains – Aquifex aeolicus
    • 1v33 - PhDNAP small subunit – Pyrocuccus horikoshii
    • 1v34 - PhDNAP small subunit + nucleotide
    • 1g71 - PfDNAP small subunit
    • 1q57 – T7DNAP/helicase (mutant) – Enterobacteria phage T7
    • 1nui – T7DNAP/helicase primase fragment (mutant)
    • 1cr0 - T7DNAP/helicase helicase domain
    • 1cr1, 1cr2, 1cr4 - T7DNAP/helicase helicase domain + nucleotide
    • 4e2k – SaDNAP – Staphylococcus aureus
    • 2lzn – SaDNAP C terminal – NMR
    • 4edg, 4edk, 4edr, 4edt, 4edv, 4ee1 – SaDNAP + nucleotide
  • Bacterial primase
    • 2r6a, 2r6c - GsdnaG helicase binding domain + helicase – Geobacillus stearothermophilus
    • 4m4w - GsdnaG helicase binding domain + helicase + DnaI
    • 1d0q - GsDNAP zinc-binding domain
    • 1z8s - GsdnaG dnaB binding domain - NMR
    • 2haj - EcdnaG catalytic domain - NMR
    • 3b39 – EcdnaG catalytic domain + DNA
    • 1t3w – EcdnaG C-terminal
    • 1eqn, 1dd9, 1dde – EcdnaG catalytic core
  • RNA polymerase from Bacteriophage T7
  • Poly(A) RNA polymerase

}}

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Karsten Theis

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