Spermidine/spermine N-acetyltransferase
From Proteopedia
(Difference between revisions)
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==3D structures of SSAT== | ==3D structures of SSAT== | ||
| + | {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Spermidine/spermine N-acetyltransferase | |
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| - | + | **[[2q4v]], [[2bei]] – hSSAT2 – human<br /> | |
| + | **[[2f5i]], [[2b5g]], [[2g3t]] – hSSAT1<br /> | ||
| + | **[[2b3u]] – hSSAT1 (mutant) | ||
| - | + | *Spermidine/spermine N-acetyltransferase complexes | |
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| + | **[[2b3v]] - hSSAT1 (mutant) + acetyl-CoA<br /> | ||
| + | **[[2fxf]] - hSSAT1 + acetyl-CoA<br /> | ||
| + | **[[2b4b]] - hSSAT1 (mutant) + BE3 + CoA<br /> | ||
| + | **[[2b4d]], [[2b58]], [[3bj7]] - hSSAT1 + CoA<br /> | ||
| + | **[[2jev]] - hSSAT1 + acetylspermine-S-CoA<br /> | ||
| + | **[[3bj8]] - hSSAT1 + spermine + CoA | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:06, 10 December 2014
Spermidine/spermine N-acetyltransferase (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products. Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs.
3D structures of SSAT
10-December-2014
