Tyrosine kinase

From Proteopedia

Revision as of 07:58, 16 December 2014

3D structures of tyrosine kinase

Updated on 16-December-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

• Non-receptor tyrosine kinases - nRTK

• Fyn tyrosine kinase

• • 1shf, 3ua6 – hTK Fyn SH3 domain – human
    
  • 3h0f, 3h0h, 3h0i - hTK Fyn SH3 domain (mutant)
    
  • 2l2p, 2lp5 - cTK Fyn SH3 domain (mutant)- chicken - NMR
    
  • 3uf4 – mTK Fyn SH3-SH2 domain – mouse
    
  • 1zbj - hTK Fyn SH3 domain – NMR
    
  • 1g83 - hTK Fyn SH2+SH3 domains (mutant)
    

• Fyn complex

• • 1fyn - hTK Fyn SH3 domain + peptide
    
  • 1nyf, 1nyg - hTK Fyn SH3 domain + peptide – NMR
    
  • 1efn, 1avz - hTK Fyn SH3 domain + HIV Nef protein
    
  • 1m27 - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide
    
  • 4d8d - hTK Fyn SH3 domain (mutant) + HIV Nef protein
    
  • 3ua7 – hTK Fyn SH3 domain + hepatitis virus peptide
    
  • 4eik - hTK Fyn SH3 domain + VSL12 peptide
    
  • 1aot, 1aou - hTK Fyn SH2 domain + phosphopeptide - NMR
    
  • 2dq7 – hTK kinase domain + staurosporine
    

• Abelson tyrosine kinase

• Abl1 SH2 domain residues 120-220

• • 1ab2 - hTK SH2 domain – NMR
    
  • 3uyo, 3t04, 3k2m - hTK SH2 domain + monobody
    

• Abl1 SH3 domain residues 60-121

• • 1ju5 - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR
    
  • 1awo - hTK SH3 domain + phosphopeptide – NMR
    
  • 1bbz - hTK SH3 domain + peptide
    
  • 2o88 - hTK SH3 domain (mutant} + peptide
    
  • 1abo - mTK SH3 domain + peptide
    
  • 1abq - mTK SH3 domain
    
  • 4jjb, 4jjc, 4jjd - hTK abl SH3 domain
    
  • 4j9b, 3egu, 3eg2, 3eg3, 3eg0, 3eg1 - hTK abl SH3 domain (mutant)
    
  • 4j9c, 4j9e, 4j9i - hTK abl SH3 domain (mutant) + p17 peptide
    
  • 4j9d, 4j9f - hTK abl SH3 domain (mutant) + p0 peptide
    
  • 4j9g, 4j9h - hTK abl SH3 domain (mutant) + p7 peptide
    

• Abl1 SH3-SH2 domain

• • 2abl - hTK SH3-SH2 domain
    
  • 2fo0 - hTK SH3-SH2 domain (mutant)
    

• Abl1 kinase domain residues 229-512

• • 2g2h - hTK kinase domain (mutant)
    
  • 1opj, 1opk - mTK kinase domain
    
  • 2g2i, 2g2f - hTK kinase domain (mutant) + peptide
    
  • 3ue4, 3cs9, 2hzi, 2hz4, 2hz0, 2hyy, 2gqg - hTK kinase domain + cancer drug
    
  • 2f4j - hTK kinase domain (mutant) + cancer drug
    
  • 3qrk, 3qri, 3qrj, 2v7a, 2e2b, 2hiw - hTK kinase domain + inhibitor
    
  • 1fpu, 1m52, 2qoh, 3kf4, 3kfa - mTK kinase domain + inhibitor
    
  • 2z60, 3dk3, 3dk6, 3dk7 - mTK kinase domain (mutant) + inhibitor
    
  • 1iep, 2hzn, 3k5v, 3ms9, 3mss, 3oxz - mTK kinase domain + cancer drug
    
  • 3ik3, 3oy3 - mTK kinase domain (mutant) + cancer drug
    

• Abl1 SH3-SH2-kinase domain

• • 1opl - hTK SH3-SH2-kinase domain (mutant}
    

• Abl1 F-actin binding domain residues 1007-1130

• • 1zzp - hTK abl F-actin binding domain – NMR
    

• Abl2 SH2 domain residues 165-273

• • 4eih - hTK SH2 domain
    
  • 2ecd - hTK SH2 domain – NMR
    

• Abl2 kinase domain residues 279-546

• • 3gvu - hTK kinase domain + Gleevec
    
  • 3hmi - hTK kinase domain + inhibitor
    
  • 2xyn - hTK kinase domain + cancer drug
    

• Abl2 C-terminal residues 1058-1182

• • 2kk1 – hTK C terminal – NMR
    

• Anaplastic lymphoma kinase (Alk)

• • 2xb7, 2xba, 3aox - hTK kinase domain + inhibitor
    
  • 4dce, 4fob, 4foc, 4fod, 4fny, 4fnz, 4joa - hTK kinase domain (mutant) + inhibitor
    
  • 2xp2 - hTK kinase domain + cancer drug
    
  • 2yfx, 4anq, 4ans - hTK kinase domain (mutant) + cancer drug
    
  • 3l9p, 3lcs, 3lct, 2yhv, 2yjr, 2yjs, 4fnw, 4fnx, 4anl - hTK kinase domain (mutant)
    

• Csk tyrosine kinase

• • 3eac - hTK SH2 domain
    
  • 3eaz - hTK SH2 domain (mutant)
    
  • 2rsy - hTK SH2 domain + CBP phosphopeptide - NMR
    
  • 1csk - hTK SH3 domain
    
  • 1jeg - hTK SH3 domain + tyrosine phosphatase peptide - NMR
    
  • 1byg - hTK kinase domain + staurosporine
    
  • 3d7t, 3d7u - hTK kinase domain (mutant) + C-Src
    
  • 1k9a - TK C terminal - rat
    

• Jak tyrosine kinase see Janus kinase

• p55-blk tyrosine kinase

• • 1blj, 1blk - mTK p55-blk SH2 domain – NMR
    

• Src tyrosine kinase

• Src tyrosine kinase SH2 domain

• • 3eac - hTK
    
  • 4f59, 3eaz - hTK (mutant)
    
  • 1f2f - cTK (mutant)
    
  • 1spr - RsvTK + phosphate – Rous sarcoma virus
    
  • 1kc2, 1sps - RsvTK + peptide
    
  • 1sha, 1shb - RsvTK + phosphopeptide
    
  • 1shd - cTK + TRKA receptor
    
  • 4f5b - hTK (mutant) + phosphotyrosine
    
  • 4f5a - hTK (mutant) + phosphate
    
  • 1o4c - hTK + phosphate
    
  • 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r - hTK + inhibitor
    
  • 1hcs, 1hct - hTK + peptide - NMR
    
  • 1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e - hTK + peptide
    
  • 1f1w - cTK (mutant) + peptide
    
  • 1p13 - cTK + peptide
    

• Src tyrosine kinase SH3 domain

• • 1srl, 1srm - cTK – NMR
    
  • 3fj5, 4jz3, 4jz4 - cTK
    
  • 4le9 - cTK (mutant)
    
  • 4hxj, 1prl - cTK + peptide
    
  • 1prm, 1rlp, 1rlq, 1nlo, 1nlp - cTK + peptide - NMR
    
  • 4hvu, 4hvv, 4hvw - cTK (mutant) + peptide
    
  • 1jeg – TK + protein-tyrosine phosphatase peptide – mouse
    

• Src tyrosine kinase kinase domain residues 253-535

• • 3of0, 2qi8 - cTK (mutant)
    
  • 1yoj - hTK (mutant)
    
  • 3tz7, 3tz8, 3tz9, 4dgg – cTK (mutant) + pyrazolin derivative
    
  • 4fic, 3uqg, 3uqf, 3u51, 3u4w, 4agw, 3qlg, 3qlf, 3g6g, 3el8, 3f6x, 2hwo, 2hwp, 2oiq, 3en4, 3en5, 3en6, 3en7, 3el7 – cTK + inhibitor
    
  • 4lgg, 4lgh, 3svv, 3oez, 3lok, 3g5d, 3f3w, 3f3v, 3geq, 3g6h, 3f3t, 3f3u, 2qlq, 2qq7, 4lgg, 4lgh – cTK (mutant) + inhibitor
    
  • 1yol, 1yom – hTK (mutant) + inhibitor
    
  • 2bdf, 2bdj – hTK + inhibitor
    
  • 1byg – hTK + staurosporine
    
  • 4mxo – hTK + cancer drug
    
  • 4mxx, 4mxy, 4mxz – hTK (mutant) + cancer drug
    
  • 3d7t, 3d7u – cTK + Csk
    
  • 3dqw, 3dqx - cTK (mutant) + ATP
    

• Src tyrosine kinase C terminal domain

• • 1yi6 - hTK
    
  • 1k9a – rTK – rat
    

• Src tyrosine kinase SH2+SH3+kinase domains residues 85-535

• • 1ksw – hTK (mutant)+ ADP derivative
    
  • 1y57 – hTK + inhibitor
    
  • 1y57 – hTK (mutant) + inhibitor
    

• Src tyrosine kinase SH2+SH3+kinase+C terminal domains

• • 1fmk – hTK
    
  • 2ptk – cTK
    
  • 2src – hTK + AMPPNP
    

• Src tyrosine kinase N terminal+SH2+SH3+kinase domains

• • 2h8h – hTK + inhibitor
    

• Lymphocyte-specific tyrosine kinase Lck

• • 1kik, 1h92 - hTK Lck SH3 domain – NMR
    
  • 2iim - hTK Lck SH3 domain
    
  • 4d8k, 1x27 - hTK Lck SH3-SH2 domain
    
  • 3lck - hTK Lck kinase domain
    

• Lck complex

• • 1lcj, 1lkk, 1lkl - hTK Lck SH2 domain (mutant) + phosphopeptide
    
  • 1cwd, 1cwe, 1ijr - hTK Lck SH2 domain + phosphopeptide
    
  • 1bhf - hTK Lck SH2 domain + peptide inhibitor
    
  • 1fbz - hTK Lck SH2 domain + inhibitor
    
  • 1bhh - hTK Lck SH2 domain + T-lymphocyte-specific TK
    
  • 1lck - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide
    
  • 1x27 - hTK Lck SH3-SH2 domain + peptide
    
  • 1qpj - hTK Lck kinase domain + staurosporin
    
  • 2of2, 2of4, 2ofu, 2ofv, 2og8, 3b2w, 3bym, 3bys, 3byu, 2zm1, 2zm4, 3byo, 2zyb, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3kmm, 3ad4, 3ad5, 3ad6, 1qpc, 1qpd, 1qpe - hTK Lck kinase domain + inhibitor
    
  • 3mpm - hTK Lck kinase domain (mutant) + inhibitor
    
  • 4c3f - hTK Lck kinase domain (mutant) + chemotype
    
  • 2pl0 - hTK Lck kinase domain + imatinib
    
  • 3kxz - hTK Lck kinase domain + probe molecule
    
  • 1q68 - hTK Lck residues 6-34 (mutant) + CD4 peptide – NMR
    
  • 1q69 - hTK Lck residues 6-34 (mutant) + CD8 – NMR
    

• Syk - spleen tyrosine kinase

• • 1xba – Syk kinase domain

• Syk complex

• • 1xbb - Syk kinase domain + Gleevec
    
  • 1xbc - Syk kinase domain + staurosporine
    
  • 3emg, 3fqe, 3fqh, 3fqs, 3srv, 4dfl, 4dfn, 3vf8, 3vf9, 3tub, 3tuc, 3tud, 4f4p, 4fyn, 4fyo, 4fz6, 4fz7, 4gfg, 4i0r, 4i0s, 4i0t, 4puz, 4pv0 - Syk kinase domain + inhibitor
    
  • 4px6 - Syk kinase domain (mutant) + inhibitor
    
  • 1csy, 1csz - Syk SH2 domain + phosphopeptide – NMR
    
  • 4fl1, 4fl2 - Syk kinase domain + ANP
    
  • 4fl3 - Syk kinase domain (mutant) + ANP
    
  • 1a81 – Syk tandem SH2 domain + T-cell surface peptide
    

• Itk tyrosine kinase

• • 1lui, 1luk, 1lum, 1lun – mTK Itk SH2 domain – NMR
    
  • 3s9k – mTK Itk SH2 domain
    
  • 2etz, 2eu0 – hTK Itk SH2 domain + phosphopeptide – NMR
    
  • 1awj, 2rn8, 2rna – mTK Itk SH3 domain – NMR
    
  • 2yuq, 2lmj – hTK Itk SH3 domain – NMR
    
  • 2k79, 2k7a – mTK Itk SH2+SH3 domains – NMR
    
  • 1sm2, 1snu, 1snx – hTK Itk kinase domain
    
  • 3miy – hTK Itk kinase domain + cancer drug
    
  • 3v5j, 3v5l, 3v8t, 3v8w – hTK Itk kinase domain + inhibitor
    
  • 3mj1, 3mj2, 3qgw, 3qgy, 4hct, 4hcu, 4hcv, 4kio – hTK Itk kinase domain (mutant) + inhibitor
    
  • 3t9t – hTK Itk kinase domain (mutant) + arthritis drug
    
  • 2e6i – hTK Itk BTK motif – NMR
    
  • 4l7s, 4m0y, 4m0z, 4m12, 4m13, 4m14, 4m15, 4mf0, 4mf1 - hTK Itk kinase domain + inhibitor
    

• Zap tyrosine kinase

• • 4k2r – hTK Zap
    
  • 2ozo - hTK Zap (mutant)
    
  • 1m61 - hTK Zap SH2 domain

• Zap complex

• • 2oq1 - hTK Zap SH2 domain + peptide
    
  • 1u59 - hTK Zap kinase domain + staurosporine

• Pyk2 tyrosine kinase

• • 3cc6, 3fzo - hTK Pyk2 kinase domain
    
  • 3gm2 - hTK Pyk2 FAT domain
    
  • 3gm3 - hTK Pyk2 FAT domain (mutant)
    
  • 4eku – hTK Pyk2 FERM domain
    
  • 2lk4 - hTK Pyk2 FAT domain – NMR
    

• Pyk2 complex

• • 3fzp - hTK Pyk2 kinase domain + ATPγS
    
  • 3fzr, 3fzs, 3fzt, 3h3c, 3et7 - hTK Pyk2 kinase domain + inhibitor
    
  • 3gm1 - hTK Pyk2 FAT domain + paxillin peptide
    
  • 4h1j - hFAK2 kinase domain + pyrazole inhibitor
    
  • 4h1m - hFAK2 kinase domain + indole inhibitor
    
  • 3u3c, 3u3f – hFAK2 FAT domain (mutant) + paxillin LD2 motif
    

• CapAB tyrosine kinase

• • 3bfv - SaTK CapA1/CapB2 – Staphylococcus aureus
    
  • 2ved - SaTK CapA1/CapB2 + Mg + ADP

• Fer tyrosine kinase

• • 2kk6 - hTK Fer SH2 domain – NMR
    

• Ptk6 tyrosine kinase

• • 1rja - hTK Ptk6 SH2 domain – NMR
    
  • 2kgt - hTK Ptk6 SH3 domain – NMR
    

• Lyn tyrosine kinase

• • 1w1f - hTK Lyn SH3 domain – NMR
    
  • 1wa7 - hTK Lyn SH3 domain + peptide – NMR
    
  • 3a4o - hTK Lyn residues 233-512 + staurosporine
    
  • 2zv7 - mTK Lyn kinase domain
    
  • 2zv8 - mTK Lyn kinase domain + AMPPNP
    
  • 2zv9 - mTK Lyn kinase domain + PP2
    
  • 2zva - mTK Lyn kinase domain + cancer drug
    

• Txk tyrosine kinase

• • 2dm0 - hTK Txk SH2 domain – NMR
    

• Yes tyrosine kinase

• • 2hda - hTK Yes SH3 domain
    

• Tec tyrosine kinase

• • 2lul - hTK Tec PH domain - NMR
    

• Fes/Fps tyrosine kinase

• • 1wqu, 2dcr - hTK Fes SH2 domain - NMR
    
  • 3bkb - hTK Fes SH2+kinase domain - NMR
    
  • 4dyl - hTK Fes F-Bar domain
    
  • 3cbl - hTK Fes SH2+kinase domain + peptide
    
  • 3cd3 - hTK Fes SH2+kinase domain + peptide + staurosporine
    
  • 4e93 - hTK TFes + inhibitor
    

• Etk tyrosine kinase

• • 3cio - EcTK Etk kinase domain – Escherichia coli
    

• Wzc tyrosine kinase

• • 3la6 - EcTK Wzc kinase domain
    

• Ros tyrosine kinase

• • 3zbf - hTK Ros kinase domain + cancer drug
    

• Tyk tyrosine kinase

• • 3lxn, 3lxp, 3nyx, 3nz0, 4e1z, 4e20, 4gfo, 4gih, 4gii, 4gj2, 4gj3 - hTK Tyk2 kinase domain (mutant) + inhibitor
    
  • 4gvj - hTK Tyk2 kinase domain (mutant) + ADP
    
  • 4po6 - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide
    

• Kit tyrosine kinase

• • 2ec8 - hNTPK Kit extracellular domain
    
  • 3g0e, 3g0f - hNTPK Kit kinase domain (mutant) + cancer drug
    
  • 2e9w, 2o26 - hNTPK Kit extracellular domain + stem cell factor
    

• Hck tyrosine kinase

• • 3hck - hTK SH2 domain - NMR
    
  • 1bu1 - hTK SH3 domain
    
  • 4hck, 5hck - hTK SH3 domain - NMR
    
  • 2oj2, 2oi3 - hTK SH3 domain + peptide - NMR
    
  • 3rbb, 3rea, 3reb - hTK SH3 domain (mutant) + HIV NEF
    
  • 3nhn - hTK SH3-SH2-linker domain
    
  • 2c0i, 2c0o, 2c0t - hTK SH3-SH2-SH1 domain + inhibitor
    
  • 2hk5 - hTK kinase domain + inhibitor
    
  • 1qcf, 3vry, 3vrz, 3vs0, 3vs1, 3vs2, 3vs3, 3vs4, 3vs5, 3vs6, 3vs7 - hTK SH3-SH2-kinase-tail domain + inhibitor
    
  • 1ad5 - hTK SH3-SH2-kinase-tail domain + AMPPNP
    
  • 2hck - hTK SH3-SH2-kinase-tail domain + quercetin
    
  • 4lud, 4lue - hTK Hck SH2+SH3+kinase domain (mutant) + fluorescent compound
    
  • 4orz - hTK Hck SH3 domain (mutant) + NEF + single domain antibody
    

• ===Receptor tyrosine kinases - RTK===

• Bruton’s tyrosine kinase

• • 2z0p - hTK Btk PH domain
    
  • 1btk – hTK Btk PH domain (mutant)
    
  • 3p08, 1k2p - hTK Btk kinase domain
    
  • 1aww, 1awx, 1qly - hTK Btk SH3 domain – NMR
    
  • 2ge9 - hTK Btk SH2 domain – NMR
    

Btk complex

1b55 - hTK Btk PH domain + inositol-tetrakisphosphate
1bwn - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate
3gen, 3ocs, 3pix, 3piy, 3piz, 3pj1, 3pj2, 3pj3, 4nwm - hTK Btk kinase domain + inhibitor
3k54, 3t9t, 4ot5, 4ot6, 4otq, 4otr - hTK Btk kinase domain (mutant) + inhibitor
3oct - hTK Btk kinase domain (mutant) + cancer drug

Fms tyrosine kinase

2i0v - hTK Fms kinase domain

Fms complex

2i0y, 2i1m - hTK Fms kinase domain + inhibitor
3dpk - hTK Fms kinase domain (mutant) + inhibitor
1flt – hTK Fms Igg-like domain + VEGF
1qty - hTK Fms domain 2 + VEGF

Mer tyrosine kinase

2dbj - hTK Mer FN2 domain – NMR
2p0c - hTK Mer kinase domain

Mer complex

3brb - hTK Mer kinase domain + ADP
3bpr, 3tcp, 4m3q, 4mh7, 4mha - hTK Mer kinase domain + inhibitor

Bone marrow tyrosine kinase

2ekx - hTK Bmx SH2 domain – NMR
2ys2 - hTK Bmx Btk motif – NMR

Bmx complex

3sxr - hTK Bmx kinase domain (mutant) + dasatinib
3sxs - hTK Bmx kinase domain (mutant) + inhibitor

ErbB tyrosine kinase

See Epidermal Growth Factor Receptor

Musk tyrosine kinase

3hkl - rTK Musk Fz-Crd domain

1. ↑ Tou WI, Chen CY. Traditional Chinese medicine as dual guardians against hypertension and cancer? J Biomol Struct Dyn. 2012 Jul;30(3):299-317. Epub 2012 Jun 12. PMID:22694277 doi:10.1080/07391102.2012.680030