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Virus protease

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===HIV-1===
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*'''HIV-1 protease'''
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[[3ixo]] - HIV1-PR subtype A<br />
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**[[3ixo]] - HIV1-PR subtype A<br />
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[[1odx]], [[ 2hb2]], [[ 2hb4]], [[ 2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br />
+
**[[1odx]], [[2hb2]], [[2hb4]], [[2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br />
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[[1rpi]], [[ 1rq9]], [[ 1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] -HIV1-PR (drug-resistant mutant) <br />
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**[[1rpi]], [[1rq9]], [[1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] - HIV1-PR (drug-resistant mutant) <br />
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[[1odw]], [[ 3kf1]], [[3hvp]], [[3phv]] - HIV1-PR<br />
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**[[1odw]], [[3kf1]], [[3hvp]], [[3phv]] - HIV1-PR<br />
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[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer
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**[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer
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''HIV-1 complexes''
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*HIV-1 protease complexes
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[[1hsg]], [[ 1hsh]], [[ 1hsi]], [[ 3oxc]], [[ 3ekv]], [[ 3ekx]], [[ 3eky]], [[ 3el1]], [[ 1ohr]], [[3ndt]], [[3nls]], [[3qoz]], [[3ndu]], [[3ndw]], [[3ndx]], [[3qoz]], [[3r0w]], [[3r0y]], [[4dqb]], [[4jec]], [[4hla]] - HIV1-PR + antiviral drug<br />
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**[[1hsg]], [[1hsh]], [[1hsi]], [[3oxc]], [[3ekv]], [[3ekx]], [[3eky]], [[3el1]], [[1ohr]], [[3ndt]], [[3nls]], [[3qoz]], [[3ndu]], [[3ndw]], [[3ndx]], [[3qoz]], [[3r0w]], [[3r0y]], [[4dqb]], [[4jec]], [[4hla]] - HIV1-PR + antiviral drug<br />
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[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br />
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**[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br />
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[[1aid]], [[ 1qbr]], [[ 1qbs]], [[ 1qbt]], [[ 1qbu]], [[ 3mxe]], [[ 3m9f ]], [[ 3kf0]], [[ 3kf1]], [[ 3kfn]], [[ 3kfp]], [[ 3kfr]], [[ 3kfs]], [[ 2wkz]], [[ 2wl0]], [[ 3gga]], [[ 3ggv]], [[ 3ggx]], [[ 2uxz]], [[ 2uy0]], [[ 1zp8]], [[ 1xl2]], [[ 1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[ 7upj]], [[ 1hxb]], [[ 1hih]], [[ 1hvr]], [[ 1hef]], [[1heg]], [[ 4phv]], [[1w5w]], [[1w5x]], [[ 1w5v]], [[ 1w5y]], [[ 1t7k]], [[ 1npa]], [[ 1npv]], [[1npw]], [[1eby]], [[1ec0]], [[ 1g2k]], [[ 1c6x]], [[ 1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[ 1hvh]], [[ 3tlh]], [[ 1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br />
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**[[1aid]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]], [[3mxe]], [[3m9f ]], [[3kf0]], [[3kf1]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[2wkz]], [[2wl0]], [[3gga]], [[3ggv]], [[3ggx]], [[2uxz]], [[2uy0]], [[1zp8]], [[1xl2]], [[1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[7upj]], [[1hxb]], [[1hih]], [[1hvr]], [[1hef]], [[1heg]], [[4phv]], [[1w5w]], [[1w5x]], [[1w5v]], [[1w5y]], [[1t7k]], [[1npa]], [[1npv]], [[1npw]], [[1eby]], [[1ec0]], [[1g2k]], [[1c6x]], [[1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[1hvh]], [[3tlh]], [[1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br />
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[[2zye]] - HIV1-PR + inhibitor - neutron<br />
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**[[2zye]] - HIV1-PR + inhibitor - neutron<br />
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[[3aid]], [[1ytg]], [[1yth]], [[2nxd]], [[2nxl]], [[2nxm]], [[2fns]], [[2fnt]], [[1zj7]], [[1zlf]], [[1zpk]], [[1zsf]], [[1zsr]],
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**[[3aid]], [[1ytg]], [[1yth]], [[2nxd]], [[2nxl]], [[2nxm]], [[2fns]], [[2fnt]], [[1zj7]], [[1zlf]], [[1zpk]], [[1zsf]], [[1zsr]], [[1cpi]], [[1m0b]], [[1iiq]], [[1fqx]], [[1a30]] - HIV1-PR + polypeptide derivative<br />
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[[1cpi]], [[1m0b]], [[1iiq]], [[1fqx]], [[1a30]] - HIV1-PR + polypeptide derivative<br />
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**[[3gi0]] - HIV1-PR covalent dimer + polypeptide<br />
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[[3gi0]] - HIV1-PR covalent dimer + polypeptide<br />
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**[[3hzc]], [[3iaw]], [[3ka2]], [[3nxn]] - HIV1-PR covalent dimer + inhibitor<br />
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[[3hzc]], [[3iaw]], [[3ka2]], [[3nxn]] - HIV1-PR covalent dimer + inhibitor<br />
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**[[1sp5]] - HIV1-PR + autoproteolytic peptide<br />
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[[1sp5]] - HIV1-PR + autoproteolytic peptide<br />
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**[[4ep2]], [[4epj]], [[4eq0]], [[4eqj]] - HIV1-PR + substrate<br />
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[[4ep2]], [[4epj]], [[4eq0]], [[4eqj]] - HIV1-PR + substrate<br />
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**[[4ejd]], [[4ejk]] - HIV1-PR + pepstatin<br />
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[[4ejd]], [[4ejk]]- HIV1-PR + pepstatin<br />
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**[[4f73]]- HIV1-PR + CA-P2<br />
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[[4f73]]- HIV1-PR + CA-P2<br />
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**[[4f74]]- HIV1-PR + MA-CA<br />
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[[4f74]]- HIV1-PR + MA-CA<br />
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**[[4f75]]- HIV1-PR + RH-IN<br />
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[[4f75]]- HIV1-PR + RH-IN<br />
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**[[4f76]]- HIV1-PR + P1-P6<br />
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[[4f76]]- HIV1-PR + P1-P6<br />
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''HIV-1 (mutant) complexes''
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*HIV-1 protease (mutant) complexes
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[[3nu3]], [[ 3nu4]], [[ 3nu5]], [[ 3nu6]], [[ 3nu9]], [[ 3nuj]], [[ 3nuo]], [[ 2qhc]], [[ 2qak]], [[ 2pym]], [[ 2pyn]], [[ 2q63]], [[ 2q64]], [[ 2fxd]], [[ 2fxe]], [[ 2fgu]], [[ 2fgv]], [[ 1sdt]], [[ 1sdu]], [[ 1sdv]], [[ 1d4y]], [[ 1d4s]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1y]], [[3d1z]], [[3d20]], [[3djk]], [[3dk1]], [[3n3i]], [[3oxv]], [[3oxw]], [[3oxx]], [[3oy4]], [[3k4v]], [[3lzs]], [[3lzu]], [[3lzv]], [[3so9]], [[3spk]], [[3ufn]], [[4dqh]], [[3s43]], [[3s53]], [[3s54]], [[3s56]], [[4dqc]], [[4dqe]], [[4dqf]], [[4dqg]] - HIV1-PR (mutant) + antiviral drug<br />
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**[[3nu3]], [[3nu4]], [[3nu5]], [[3nu6]], [[3nu9]], [[3nuj]], [[3nuo]], [[2qhc]], [[2qak]], [[2pym]], [[2pyn]], [[2q63]], [[2q64]], [[2fxd]], [[2fxe]], [[2fgu]], [[2fgv]], [[1sdt]], [[1sdu]], [[1sdv]], [[1d4y]], [[1d4s]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1y]], [[3d1z]], [[3d20]], [[3djk]], [[3dk1]], [[3n3i]], [[3oxv]], [[3oxw]], [[3oxx]], [[3oy4]], [[3k4v]], [[3lzs]], [[3lzu]], [[3lzv]], [[3so9]], [[3spk]], [[3ufn]], [[4dqh]], [[3s43]], [[3s53]], [[3s54]], [[3s56]], [[4dqc]], [[4dqe]], [[4dqf]], [[4dqg]] - HIV1-PR (mutant) + antiviral drug<br />
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[[2aid]], [[ 1hpo]], [[ 1tcx]], [[ 1gnm]], [[ 1gnn]], [[ 1gno]], [[ 1kzk]], [[ 3ok9]], [[ 3i8w]], [[ 3i7e]], [[ 3bxr]], [[ 3bxs]], [[ 2hc0]], [[ 2psu]], [[ 2psv]], [[ 2fle]], [[ 2f3k]], [[ 2ien]], [[ 2fdd]], [[ 2fde]], [[ 1t7i]], [[ 1t3r]], [[ 1mrw]], [[ 1mrx]], [[ 1msm]], [[ 1msn]], [[ 1bv9]], [[3h5b]], [[3kdb]], [[3kdc]], [[3kdd]], [[3a2o]], [[3bc4]], [[3fx5]], [[3i6o]], [[3st5]], [[3qaa]], [[3qbf]], [[3qih]], [[3qn8]], [[3qp0]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[4dfg]] - HIV1-PR (mutant) + inhibitor<br />
+
**[[2aid]], [[1hpo]], [[1tcx]], [[1gnm]], [[1gnn]], [[1gno]], [[1kzk]], [[3ok9]], [[3i8w]], [[3i7e]], [[3bxr]], [[3bxs]], [[2hc0]], [[2psu]], [[2psv]], [[2fle]], [[2f3k]], [[2ien]], [[2fdd]], [[2fde]], [[1t7i]], [[1t3r]], [[1mrw]], [[1mrx]], [[1msm]], [[1msn]], [[1bv9]], [[3h5b]], [[3kdb]], [[3kdc]], [[3kdd]], [[3a2o]], [[3bc4]], [[3fx5]], [[3i6o]], [[3st5]], [[3qaa]], [[3qbf]], [[3qih]], [[3qn8]], [[3qp0]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[4dfg]] - HIV1-PR (mutant) + inhibitor<br />
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[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
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**[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
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[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
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**[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
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[[1zbg]], [[ 1z8c]], [[ 2az9]], [[ 2azc]], [[ 2a1e]], [[ 1lzq]], [[ 1d4k]], [[ 1d4l]], [[ 1a8k]], [[ 1a94]], [[ 1axa]], [[3dox]], [[3d3t]], [[4fl8]] - HIV1-PR (mutant) + polypeptide derivative<br />
+
**[[1zbg]], [[1z8c]], [[2az9]], [[2azc]], [[2a1e]], [[1lzq]], [[1d4k]], [[1d4l]], [[1a8k]], [[1a94]], [[1axa]], [[3dox]], [[3d3t]], [[4fl8]] - HIV1-PR (mutant) + polypeptide derivative<br />
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[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane<br />
+
**[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane<br />
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[[3b7v]], [[3b80]], [[3mim]] - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate<br />
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**[[3b7v]], [[3b80]], [[3mim]] - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate<br />
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[[3nxe]] - HIV1-PR covalent dimer (mutant) + inhibitor<br />
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**[[3nxe]] - HIV1-PR covalent dimer (mutant) + inhibitor<br />
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[[4flg]], [[4fm6]] - HIV1-PR (mutant) + reaction intermediate
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**[[4flg]], [[4fm6]] - HIV1-PR (mutant) + reaction intermediate
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''HIV-1 (drug-resistant mutant) complexes''
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*HIV-1 protease (drug-resistant mutant) complexes
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[[3el4]], [[ 3el9]], [[ 3em3]], [[ 3em4]], [[ 3em6]], [[ 3ggt]], [[ 3ggu]], [[ 1t7j]], [[ 1rv7]], [[ 1n49]], [[ 1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]], [[3ucb]], [[3uhl]], [[3ttp]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
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**[[3el4]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[3ggt]], [[3ggu]], [[1t7j]], [[1rv7]], [[1n49]], [[1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]], [[3ucb]], [[3uhl]], [[3ttp]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
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[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br />
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**[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br />
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[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
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**[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
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[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
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**[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
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[[2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor<br />
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**[[2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor<br />
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===HIV-2===
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*'''HIV-2 protease'''
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[[1jld]] - HIV2-PR<br />
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**[[1jld]] - HIV2-PR<br />
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[[1hii]] - HIV2-PR + inhibitor<br />
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**[[1hii]] - HIV2-PR + inhibitor<br />
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[[5upj]], [[ 6upj]], [[ 3upj]], [[ 4upj]] - HIV2-PR (mutant) + inhibitor<br />
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**[[5upj]], [[ 6upj]], [[ 3upj]], [[ 4upj]] - HIV2-PR (mutant) + inhibitor<br />
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[[1ida]], [[ 1idb]], [[ 2mip]] - HIV2-PR + polypeptide derivative
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**[[1ida]], [[ 1idb]], [[ 2mip]] - HIV2-PR + polypeptide derivative
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===Feline Immunodeficiency Virus-PR===
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*'''Feline Immunodeficiency virus protease'''
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[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
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**[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
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[[3ogp]], [[3ogq]] - FIV-PR residues 39-154 (mutant) + drug<br />
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**[[3ogp]], [[3ogq]] - FIV-PR residues 39-154 (mutant) + drug<br />
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[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
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**[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
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[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
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**[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
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===Simian Immunodeficiency Virus-PR===
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*'''Simian Immunodeficiency virus protease'''
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[[2sam]] - SIV-PR + inhibitor<br />
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**[[2sam]] - SIV-PR + inhibitor<br />
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[[1az5]] - SIV-PR (mutant)<br />
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**[[1az5]] - SIV-PR (mutant)<br />
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===XMRV-PR===
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*'''Xenotropic murine leukemia virus protease'''
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[[3nr6]] – XMRV-PR P14<br />
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**[[3nr6]] – XMRV-PR P14<br />
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[[3p1g]] – XMRV-PR RNase H domain (mutant)
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**[[3p1g]] – XMRV-PR RNase H domain (mutant)
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===Rous sarcoma virus protease===
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*'''Rous sarcoma virus protease'''
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[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus
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**[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus
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===Human Cytomegalovirus protease===
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*'''Human Cytomegalovirus protease'''
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[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus 5<br />
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**[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus 5<br />
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[[1wpo]] – CMVP<br />
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**[[1wpo]] – CMVP<br />
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[[2wpo]] - CMVP (mutant) + inhibitor
+
**[[2wpo]] - CMVP (mutant) + inhibitor
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===Varicella-Zoster virus protease===
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*'''Varicella-Zoster virus protease'''
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[[1vzv]] - VZVP (mutant) – human herpes virus
+
**[[1vzv]] - VZVP (mutant) – human herpes virus
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===Equine infectious anemia virus protease===
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*'''Equine infectious anemia virus protease'''
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[[2fmb]] – EIAVP (mutant) + inhibitor
+
**[[2fmb]] – EIAVP (mutant) + inhibitor
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===Hepatitis A virus protease===
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*'''Hepatitis A virus protease'''
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[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
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**[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
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===Orf 17===
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*'''Orf 17'''
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[[3njq]] – hOrf 17 - human herpes virus 8
+
**[[3njq]] – hOrf 17 - human herpes virus 8
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===Dengue virus protease===
+
*'''Dengue virus protease'''
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[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
+
**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
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[[3u1j]] – DvNs2b + BPTI<br />
+
**[[3u1j]] – DvNs2b + BPTI<br />
-
[[2fom]] - DvNs2b + DvNs3<br />
+
**[[2fom]] - DvNs2b + DvNs3<br />
-
[[2whx]] – DvNs3 residues 1475-2092
+
**[[2whx]] – DvNs3 residues 1475-2092
-
===Herpes simplex virus protease===
+
*'''Herpes simplex virus protease'''
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[[1at3]] – HSV II – human herpesvirus 2
+
**[[1at3]] – HSV II – human herpesvirus 2
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===Foot-and-Mouth Disease virus protease===
+
*'''Foot-and-Mouth Disease virus protease'''
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[[2bhg]] – FMDV – Foot-and-mouth disease virus
+
**[[2bhg]] – FMDV – Foot-and-mouth disease virus
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===Infectious Bronchitis virus protease===
+
*'''Infectious Bronchitis virus protease'''
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[[2q6d]] – IBV – infectious bronchitis virus <br />
+
**[[2q6d]] – IBV – infectious bronchitis virus <br />
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[[2q6f]] – IBV + inhibitor
+
**[[2q6f]] – IBV + inhibitor
-
===Yellowtail ascites virus protease===
+
*'''Yellowtail ascites virus protease'''
-
 
+
-
[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
+
 +
**[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:53, 17 December 2014

Template:STRUCTURE 1odw

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. See also


3D Structures of Virus proteases

Updated on 17-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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