4l5b
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5b RCSB], [http://www.ebi.ac.uk/pdbsum/4l5b PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5b RCSB], [http://www.ebi.ac.uk/pdbsum/4l5b PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 08:17, 24 December 2014
Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
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