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2xow
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xow' size='340' side='right' caption='[[2xow]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='2xow' size='340' side='right' caption='[[2xow]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The August 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOW OCA]. <br> | + | <table><tr><td colspan='2'>[[2xow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The August 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XOW FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=ISM:5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC+ACID'>ISM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=ISM:5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC+ACID'>ISM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ic8|2ic8]], [[2xov|2xov]], [[2irv|2irv]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ic8|2ic8]], [[2xov|2xov]], [[2irv|2irv]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rhomboid_protease Rhomboid protease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.105 3.4.21.105] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xow RCSB], [http://www.ebi.ac.uk/pdbsum/2xow PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xow RCSB], [http://www.ebi.ac.uk/pdbsum/2xow PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLPG_ECOLI GLPG_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.<ref>PMID:17099694</ref> <ref>PMID:16216077</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The structural basis for catalysis and substrate specificity of a rhomboid protease.,Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M EMBO J. 2010 Oct 1. PMID:20890268<ref>PMID:20890268</ref> | The structural basis for catalysis and substrate specificity of a rhomboid protease.,Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M EMBO J. 2010 Oct 1. PMID:20890268<ref>PMID:20890268</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Rhomboid protease|Rhomboid protease]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Rhomboid Protease GlpG]] | [[Category: Rhomboid Protease GlpG]] | ||
[[Category: Rhomboid protease]] | [[Category: Rhomboid protease]] | ||
| - | [[Category: Andreeva, A | + | [[Category: Andreeva, A]] |
| - | [[Category: Christova, Y | + | [[Category: Christova, Y]] |
| - | [[Category: Freeman, M | + | [[Category: Freeman, M]] |
| - | [[Category: Strisovsky, K | + | [[Category: Strisovsky, K]] |
| - | [[Category: Verhelst, S | + | [[Category: Verhelst, S]] |
| - | [[Category: Vinothkumar, K R | + | [[Category: Vinothkumar, K R]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Intramembrane protease]] | [[Category: Intramembrane protease]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 23:46, 24 December 2014
STRUCTURE OF GLPG IN COMPLEX WITH A MECHANISM-BASED ISOCOUMARIN INHIBITOR
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