3ckl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CKL FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CKL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1B1, ST1B2, SULT1B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1B1, ST1B2, SULT1B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [http://www.ebi.ac.uk/pdbsum/3ckl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [http://www.ebi.ac.uk/pdbsum/3ckl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Sulfotransferase|Sulfotransferase]] | *[[Sulfotransferase|Sulfotransferase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bochkarev, A | + | [[Category: Bochkarev, A]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Dong, A | + | [[Category: Dong, A]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Kozieradzki, I | + | [[Category: Kozieradzki, I]] |
| - | [[Category: Loppnau, P | + | [[Category: Loppnau, P]] |
| - | [[Category: Min, J | + | [[Category: Min, J]] |
| - | [[Category: Pan, P W | + | [[Category: Pan, P W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Tempel, W | + | [[Category: Tempel, W]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Human cytosolic sulfotransferase]] | [[Category: Human cytosolic sulfotransferase]] | ||
[[Category: Lipid metabolism]] | [[Category: Lipid metabolism]] | ||
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[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Steroid metabolism]] | [[Category: Steroid metabolism]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Sult1b1]] | [[Category: Sult1b1]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 01:51, 25 December 2014
Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol
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Categories: Homo sapiens | Arrowsmith, C H | Bochkarev, A | Bountra, C | Dong, A | Edwards, A M | Kozieradzki, I | Loppnau, P | Min, J | Pan, P W | Structural genomic | Tempel, W | Weigelt, J | Human cytosolic sulfotransferase | Lipid metabolism | Resveratrol | Sgc | Steroid metabolism | Sult1b1 | Transferase
