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2r9f

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2r9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2r9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9F FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K2Z:BENZYL+[(1S)-1-{[(1S,2S)-1-ETHYL-2-HYDROXY-3-{[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]AMINO}-3-OXOPROPYL]CARBAMOYL}-3-METHYLBUTYL]CARBAMATE'>K2Z</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K2Z:BENZYL+[(1S)-1-{[(1S,2S)-1-ETHYL-2-HYDROXY-3-{[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]AMINO}-3-OXOPROPYL]CARBAMOYL}-3-METHYLBUTYL]CARBAMATE'>K2Z</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kxr|1kxr]], [[2g8j|2g8j]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[2g8e|2g8e]], [[2r9c|2r9c]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kxr|1kxr]], [[2g8j|2g8j]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[2g8e|2g8e]], [[2r9c|2r9c]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9f RCSB], [http://www.ebi.ac.uk/pdbsum/2r9f PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9f RCSB], [http://www.ebi.ac.uk/pdbsum/2r9f PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Calpain-1]]
[[Category: Calpain-1]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Campbell, R L.]]
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[[Category: Campbell, R L]]
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[[Category: Davies, P L.]]
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[[Category: Davies, P L]]
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[[Category: Qian, J.]]
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[[Category: Qian, J]]
[[Category: Alpha-ketoamide]]
[[Category: Alpha-ketoamide]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 03:54, 25 December 2014

Calpain 1 proteolytic core inactivated by ZLAK-3002, an alpha-ketoamide

2r9f, resolution 1.60Å

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