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2qrn
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qrn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qrn RCSB], [http://www.ebi.ac.uk/pdbsum/2qrn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qrn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qrn RCSB], [http://www.ebi.ac.uk/pdbsum/2qrn PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Deoxycytidine kinase]] | [[Category: Deoxycytidine kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ealick, S E | + | [[Category: Ealick, S E]] |
| - | [[Category: Soriano, E V | + | [[Category: Soriano, E V]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
| - | [[Category: Deoxycytidine kinase]] | ||
[[Category: Deoxycytidine monophosphate]] | [[Category: Deoxycytidine monophosphate]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
Revision as of 18:46, 25 December 2014
Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex
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