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	== Introduction ==		== Introduction ==
-	Squalene-hopene cyclase uses squalene as a substrate and creates hopene as a product. It is an integral step in the cholesterol biosynthesis pathway. The enzyme is found in many species of bacteria, but most commonly isolated from ''Alicyclobacillus acidocaldarius''. It is considered to be an evolutionary primitive form that operates in the absence of oxygen.	+	[http://en.wikipedia.org/wiki/Lanosterol_synthase Lanosterol synthase] is an important enzyme in the cholesterol biosynthesis pathway, it converts [http://en.wikipedia.org/wiki/2,3-Oxidosqualene 2,3-Oxidosqualene] to [http://en.wikipedia.org/wiki/Lanosterol Lanosterol].
	== Structure ==		== Structure ==

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Revision as of 23:25, 23 February 2015

This Sandbox is Reserved from 20/01/2015, through 30/04/2016 for use in the course "CHM 463" taught by Mary Karpen at the Grand Valley State University. This reservation includes Sandbox Reserved 987 through Sandbox Reserved 996.

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Contents 1 Oxidosqualene Cyclase 1.1 Introduction 1.2 Structure 1.3 Function 1.3.1 Cholesterol Biosynthesis 1.4 Disease 1.5 Relevance 1.6 Structural highlights 1.7 References

Oxidosqualene Cyclase

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This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Introduction

Lanosterol synthase is an important enzyme in the cholesterol biosynthesis pathway, it converts 2,3-Oxidosqualene to Lanosterol.

Structure

These are the for this protein

Function

The enzyme oxidosqualene cyclase carries out the most complex phase of cholesterol synthesis. It takes a lengthy skinny carbon chain, oxidosqualene, and folds it to create a cyclic compound composed of four connected rings.

Cholesterol Biosynthesis

Cholesterol

Disease

Relevance

Structural highlights

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References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644