Deoxycytidine kinase
From Proteopedia
(Difference between revisions)
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**[[1p5z]], [[1p62]], [[2a7q]] – hDCK + ADP + chemotherapy agent – human<br /> | **[[1p5z]], [[1p62]], [[2a7q]] – hDCK + ADP + chemotherapy agent – human<br /> | ||
**[[2no9]], [[2noa]], [[2no0]], [[2no6]], [[2zi9]] – hDCK (mutant) + ADP + chemotherapy agent <br /> | **[[2no9]], [[2noa]], [[2no0]], [[2no6]], [[2zi9]] – hDCK (mutant) + ADP + chemotherapy agent <br /> | ||
| - | **[[2zia]] – hDCK (mutant) + UDP + chemotherapy agent <br /> | + | **[[2zia]], [[4kcg]] – hDCK (mutant) + UDP + chemotherapy agent <br /> |
*dCK complex with nucleoside | *dCK complex with nucleoside | ||
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**[[2qrn]] – hDCK + UDP + CMP<br /> | **[[2qrn]] – hDCK + UDP + CMP<br /> | ||
**[[2qro]] – hDCK + UDP + AMP<br /> | **[[2qro]] – hDCK + UDP + AMP<br /> | ||
| - | **[[3ipx]] – hDCK + ADP + | + | **[[3ipx]] – hDCK + ADP + inhibitor<br /> |
| - | **[[3ipy]] – hDCK + | + | **[[3ipy]] – hDCK + inhibitor<br /> |
**[[3qej]] – hDCK (mutant) + UDP <br /> | **[[3qej]] – hDCK (mutant) + UDP <br /> | ||
| - | **[[4jlj]], [[4jlk]], [[4jlm]], [[4jln]], [[4l5b]] - hDCK (mutant) + UDP + inhibitor<br /> | + | **[[4jlj]], [[4jlk]], [[4jlm]], [[4jln]], [[4l5b]], [[4q18]], [[4q19]], [[4q1a]], [[4q1b]], [[4q1c]], [[4q1d]], [[4q1e]], [[4q1f]] - hDCK (mutant) + UDP + inhibitor<br /> |
**[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br /> | **[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:36, 23 March 2015
Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deficiency of DCK causes resistance to these agents.
3D Structures of deoxycytidine kinase
Updated on 23-March-2015
