5abi
From Proteopedia
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| - | ''' | + | ==Identification of a Water-Bridge Mediated Recognition Module at the mRNA Cap-Binding Interface of eIF4E== |
| - | + | <StructureSection load='5abi' size='340' side='right' caption='[[5abi]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5abi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5abi RCSB], [http://www.ebi.ac.uk/pdbsum/5abi PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: Brown, C | + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brown, C J]] | ||
[[Category: Lama, D]] | [[Category: Lama, D]] | ||
| - | [[Category: Verma, C | + | [[Category: Verma, C S]] |
| + | [[Category: Cap binding]] | ||
| + | [[Category: Eif4e]] | ||
| + | [[Category: Protein translation]] | ||
| + | [[Category: Translation]] | ||
Revision as of 12:33, 2 September 2015
Identification of a Water-Bridge Mediated Recognition Module at the mRNA Cap-Binding Interface of eIF4E
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