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Calpain
From Proteopedia
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* '''CAP8''' and '''CAP9''' are involved in the mucosal defense against stress-induced gastropathies.<br /> | * '''CAP8''' and '''CAP9''' are involved in the mucosal defense against stress-induced gastropathies.<br /> | ||
* '''CAP9''' has been identified as the tumor suppressor for gastric cancer.<br /> | * '''CAP9''' has been identified as the tumor suppressor for gastric cancer.<br /> | ||
| - | * '''CAP13''' is expressed in testis and lungs. | + | * '''CAP13''' is expressed in testis and lungs. |
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| + | ==Disease== | ||
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| + | CAP3 defects lead to a certain muscular dystrophy. Defective CAPs have a role in neurodegeneration. | ||
== Structural highlights == | == Structural highlights == | ||
| - | CAP is a heterodimer containing a small 28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. | + | CAP is a heterodimer containing a small 28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. CAP undergoes conformational change upon binding of Ca+2 ions resulting in closing of its active site cleft and activation. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:58, 16 November 2015
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3D structures of calpain
Updated on 16-November-2015
