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Complexin
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3rk3| PDB=3rk3 | SIZE=400| SCENE= |right|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }} | {{STRUCTURE_3rk3| PDB=3rk3 | SIZE=400| SCENE= |right|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }} | ||
| + | <StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''> | ||
| - | '''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion. | ||
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| - | {{TOC limit|limit=2}} | ||
| + | '''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:11742345</ref> | ||
| + | </StructureSection> | ||
==3D structures of complexin== | ==3D structures of complexin== | ||
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[[3rk3]], [[3rl0]] - CPLX + SNARE – human | [[3rk3]], [[3rl0]] - CPLX + SNARE – human | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:34, 14 December 2015
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3D structures of complexin
Updated on 14-December-2015
1kil – CPLX + SNARE – rat
3rk3, 3rl0 - CPLX + SNARE – human
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
