Complexin
From Proteopedia
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<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''> | <StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''> | ||
| + | == Function == | ||
| + | |||
| + | '''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref> | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin. | ||
| - | '''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref> | ||
</StructureSection> | </StructureSection> | ||
==3D structures of complexin== | ==3D structures of complexin== | ||
Revision as of 09:48, 14 December 2015
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3D structures of complexin
Updated on 14-December-2015
1kil – CPLX + SNARE – rat
3rk3, 3rl0 - CPLX + SNARE – human
References
- ↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200
