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Complexin

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== Structural highlights ==
== Structural highlights ==
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<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene>.
+
<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref>
</StructureSection>
</StructureSection>

Revision as of 12:36, 20 December 2015

Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry 3rk3)

Drag the structure with the mouse to rotate

3D structures of complexin

Updated on 20-December-2015

1kil – CPLX + SNARE – rat

3rk3, 3rl0 - CPLX + SNARE – human

References

  1. ↑ Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002 Nov 1;277(44):41652-6. Epub 2002 Aug 27. PMID:12200427 doi:http://dx.doi.org/10.1074/jbc.M205044200
  2. ↑ Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414 doi:10.1038/nsmb.2101

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Michal Harel, Alexander Berchansky

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