Deoxycytidine kinase
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1p62| PDB=1p62 | SIZE=350| SCENE= |right|CAPTION= Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) [[1p62]] }} | ||
| - | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deficiency of DCK causes resistance to these agents. | ||
| + | <StructureSection load='1p62' size='350' side='right' caption='Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) (PDB entry [[1p62]])' scene=''> | ||
| + | == Function == | ||
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| + | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. <ref>PMID:11742345</ref> | ||
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| + | == Relevance == | ||
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| + | Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents. | ||
| + | </StructureSection> | ||
== 3D Structures of deoxycytidine kinase == | == 3D Structures of deoxycytidine kinase == | ||
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**[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br /> | **[[3mjr]] – hDCK + UDP + hydroxyethoxymethylguanine<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:31, 23 December 2015
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3D Structures of deoxycytidine kinase
Updated on 23-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
