Deoxycytidine kinase
From Proteopedia
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<StructureSection load='1p62' size='350' side='right' caption='Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) (PDB entry [[1p62]])' scene=''> | <StructureSection load='1p62' size='350' side='right' caption='Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) (PDB entry [[1p62]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. <ref>PMID: | + | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. <ref>PMID:20614893</ref> |
== Relevance == | == Relevance == | ||
Revision as of 08:34, 23 December 2015
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3D Structures of deoxycytidine kinase
Updated on 23-December-2015
References
- ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
