Sandbox Reserved 1120

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(Première mise en forme de la page + petite intro)
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==SRY protein (AKA TDF protein)==
==SRY protein (AKA TDF protein)==
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<StructureSection load='1hry' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1hry' size='340' side='right' caption='The SRY protein linked to DNA' scene=''>
The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance (MIS gene)
The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance (MIS gene)
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==History==
==History==
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It has been shown that a mutation of SRY increase male to female sex reversal for 15% '''REF NECESSAIRE'''
==Structure==
==Structure==
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===The hSRY-HMG domain===
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It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins.
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Twisted L shape : Concave surface. 3 helices & N and C end strands.
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Binds the DNA by its minor groove.
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===General structure of SRY===
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3 domains:
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* N-term domain
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* Central domain
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* C-term domain
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== Function ==
== Function ==
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===Sex determining===
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* MSI
C'est une protéine de l'ambiance. Elle peut tout faire.
C'est une protéine de l'ambiance. Elle peut tout faire.

Revision as of 19:35, 30 December 2015

This Sandbox is Reserved from 15/12/2015, through 15/06/2016 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1120 through Sandbox Reserved 1159.
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SRY protein (AKA TDF protein)

The SRY protein linked to DNA

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References

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